脐带间充质干细胞移植治疗重症支气管肺发育不良的护理

Nursing care of umbilical cord mesenchymal stem cells transplantation for treating severe bronchopulmonary dysplasia

目的掌握人脐带间充质干细胞(hUC-MSCs)移植治疗早产儿重症支气管肺发育不良(BPD)的护理流程,初步评估其安全性及效果。方法该研究经静脉移植hUC-MSCs。移植前进行家属心理护理,帮助家属消除疑虑,建立信心,同时积极做好移植前患儿病情评估,建立静脉通道,输注前过滤hUC-MSCs;移植过程中确保管路通畅,严格无菌操作,监测患儿生命体征,警惕不良反应发生;移植术后严密观察病情及做好记录,预防术后感染,持续做好家属心理护理。结果13例罹患重症BPD的早产儿行hUC-MSCs移植均无不良反应发生,8例患儿临床有好转,9例患儿影像学有好转。结论该研究初步证实hUC-MSCs移植治疗早产儿重症BPD是安全且有效的。

Objective To master the nursing process of human umbilical cord mesenchymal stem cells(hUC-MSCs)transplantation for the treatment of severe bronchopulmonary dysplasia(BPD)in premature infants,and to preliminarily evaluate its safety and effect.Methods hUC-MSCs were transplanted by vein in this study.Conducting the psychological nursing of family members before transplantation could help the family members to dispel the doubts and build the confidence.At the same time,the evaluation of neonatal patient′s disease condition before transplantation should be actively and well done,intravenous channels should be established,and hUC-MSCs should be filtered before infusion.During transplantation,the pipelines should be unobstructed,the aseptic operation should be strictly carried out,the vital signs of neonatal patients should be monitored and adverse reactions should be alerted.After transplantation,the patients′disease condition should be closely observed and the psychological nursing of family members should be done well.Results There were no adverse reactions in 13 preterm infants with severe BPD undergoig hUC-MSCs transplantation,8 cases were improved clinically and 9 cases were improved in imaging.Conclusion This study preliminarily confirms that the hUC-MSCs transplantation is safe and effective for treating severe BPD in premature infants.