西藏高海拔地区妊娠期妇女宫颈HPV感染状况及相关因素分析

Characterize the infection rate of cervical HPV during pregnancy and its risk factors in the Tibet highland

目的了解西藏高海拔地区妊娠期妇女宫颈人乳头瘤病毒(HPV)感染状况及相关危险因素。方法选取2018年4月—2019年4月在拉萨市人民医院及拉萨市妇幼保健院产科门诊初次产检的500例孕妇,1例因标本取材问题未能出结果,故最终499例孕妇纳入研究,孕妇年龄17~48岁,筛查时孕周4~20周,其中藏族452例(90.6%)。进行HPV分型及TCT检测,统计感染率及感染相关因素。结果西藏高海拔地区孕妇HPV各亚型感染者144例,总感染率为28.9%,高危型感染率为24.2%,低危型感染率为4.6%;细胞学异常者5例,异常率1%,其中低度病变(LSIL)为2例,非典型鳞状细胞意义不明确(ASC-US)为3例。结论西藏高海拔地区妊娠期妇女HPV感染率及高危型感染率均与内地一线城市相当,低于内地三线城市。西藏高海拔地区妊娠期进行宫颈HPV、TCT检测是安全可行的策略。

Objective To investigate the status and risk factors of cervical human papillomavirus(HPV)infection in pregnant women at the Tibet highland.MethodsFrom April 2018 to April 2019,499 pregnant women with HPV and TCT tests were collected from the obstetrics clinic of Lhasa People′s Hospital and Lhasa Maternal and Child Health Hospital.The samples were aged from 17 to 48 years old,and 452(90.6%)of them were Tibetan.Infection rate of HPV was calculated,and infection-related risk factors were analyzed.ResultsThere were 144 HPV cases,and the total infection rate was 28.9%.For high-or low-risk subtype,the infection rate was 24.2%or 4.6%,respectively.There were also 5 cases with abnormal cytology,2 cases with LSIL and 3 cases with ASC-US.ConclusionThe HPV infection rate and high-risk infection rate in pregnant women in Tibet are similar to those in the first-tier cities of mainland,but lower than those in the third-or fourth tier cities.Cervical HPV and TCT detection during pregnancy in Tibet is a safe and feasible strategy.