串联环化反应合成噻吩并[2,3-d]嘧啶类化合物的研究进展

Recent Progress in the Synthesis of Thieno[2,3-d]pyrimidine Compounds via Tandem Cyclization

噻吩并[2,3-d]嘧啶类化合物是一类重要的有机合成中间体和药理活性分子,具有广阔的医药应用前景和重要的研究意义,因此其合成也备受关注.现有的合成方法主要是通过串联环化反应或一锅多组分反应,结合微波辅助法或新型催化剂以达到缩短反应时间、减少反应步骤、提高产率、降低成本等目的.较全面地概述了近十年来,特别是近五年来通过串联环化反应合成噻吩并[2,3-d]嘧啶类化合物的研究进展,对该领域存在的问题和局限性进行了总结,并对今后的发展作出展望,以期对相关领域的研究起到一定的辅助和推动作用.

Thieno[2,3-d]pyrimidine compounds are an important class of organic synthesis intermediates and pharmacologically active molecules,which not only have broad medical application prospect,but also worth researching.Therefore the synthesis of them has attracted much attention.The previous methods mainly apply tandem cyclization or one-pot multi-component reaction combined with microwave-assisted reaction or new catalysts to reach the purpose of shortening reaction time,reducing steps,enhancing yields and lowering costs.In this paper,the recent progress in the synthesis of thieno[2,3-d]pyrimidine compounds via tandem cyclization in recent ten years,especially in the latest five years,is reviewed.The problems and limitations faced are discussed,and the development directions are also prospected.