钯催化的烯丙基取代反应中烯丙基醇的高效活化

Efficient Activation of Allylic Alcohols in Pd-Catalyzed Allylic Substitution Reactions

由于烯丙基醇的碳-氧键较为惰性,烯丙基醇的高效活化是烯丙基取代反应研究中的一个重要方向.近年来,非经典的外加酸活化以及无外加活化剂条件下烯丙基醇的高效活化及取代反应得到了快速发展,为烯丙基醇的高效活化提供了新的研究思路.根据烯丙基醇的活化方式及机制对这些研究进展进行了简要论述.

Owing to the poor leaving character of hydroxy group,the efficient activation of allylic alcohols is important to allylic substitution reaction.In recent years,the efficient activation of allylic alcohols by non-typical acid activators and even no extra activators has been rapidly developed,and provides a novel approach to efficient activation of allylic alcohols.The recent developments in this area are summarized on the basis of different activation modes and mechanisms.