镍(Ⅱ)催化芳香烃氧化-偶联反应

Ni(Ⅱ)-Catalyzed Oxidative Coupling of Arenes

以二叔丁基过氧化物为氧化剂,1,4-二氮杂二环[2.2.2]辛烷(DABCO)为助催化剂,通过乙酰丙酮镍催化的芳香烃偶联反应,建立了一种制备联苄化合物的方法.该方法对不同芳烃底物具有耐受性,其中,异丙苯最容易发生反应,联苄的收率达到73%.优化条件下芳香烃与环烷烃也可发生交叉偶联作用,但伴随两种底物的自偶联反应.该方法能有效抑制醇、醛和酸的产生.

A protocol for the synthesis of bibenzyls via nickel acetylacetonate-catalyzed coupling of arenes was devloped using di-tert-butylperoxide as the oxidant with the asistance of 1,4-diazabicyclo[2.2.2]octane(DABCO).The process tolerated to different substrates,among of which,isopropylbenzene provided the most satisfactory yield of bibenzyls in 73%yield.The cross-coupling of arenes with cycloalkanes was also realized under the optimal reaction conditions but accompanied with the self-coupling of substrates.The method could effectively restrain the formation of alcohol,aldehyde,acid.