41例地高辛中毒的临床特点及影响因素分析

Analysis of Clinical Character istics and Influencing Factors of 41 Cases of Digoxin Toxication

目的分析地高辛中毒的临床特点及影响因素,为临床合理用药提供参考.方法选取首都医科大学密云教学医院(以下简称"我院")2017年1月~2019年9月收治或住院期间地高辛中毒患者共41例,对相关资料进行回顾性分析.结果41例患者中,男14例,女27例,平均年龄(76.39±8.20)岁,25例患者伴肾功能损伤,41例患者中29例(70.73%)患者采用0.125mg/d,12例(29.27%)患者采用>0.125mg/d.90.24%的患者地高辛血药浓度>2.0ng·mL^-1.地高辛中毒表现主要为胃肠道不适及心脏毒性.结论地高辛治疗窗窄且存在明显个体差异,血清浓度影响因素复杂,应密切监测地高辛血药浓度并加强监护,促进临床合理用药.

Objective To analyze the clinical characteristics and influencing factors of digoxin toxication,so as to provide references for clinical rational medication.Methods A total of 41 patients with digoxin toxication during the admission or hospitalization period from January 2017 to September 2019 in Capital Medical University Miyun Hospital(hereinafter referred to as"our hospital")were selected for retrospective analysis.Results The average age of 41 patients was(76.39±8.20)years old,including 14 cases of male and 27 cases of female.25 patients was accompanied hy renal insufficiency.Of the 41 patients,29 patients(70.73%),the daily dose of digoxin was 0.125 mg,12 patients(29.27%),the daily dose of digoxin was greater than 0.125 mg/d.The blood concentration of digoxin was greater than 2.Ong·mL^-1 in 90.24%of the patients.The performance of digoxin toxication is mainly gastrointestinal discomfort and cardiotoxicity.Conclusion The treatment of digoxin toxication is limited and has obvious individual differences,and the influencing factors of serum concentration are complex,therefore,it is necessary to closely nwnitor the blood concentration of digoxin to promote clinical rational medication.