黑色丘疹性皮病与脂溢性角化病临床、组织病理对比分析

Clinical and histopathological analysis of dermatosis papulosa nigra and seborrheic keratosis

目的通过黑色丘疹性皮病(DPN)与脂溢性角化病(SK)临床、组织病理学特征分析,明确二者之间的相关性。方法对2018年12月至2020年4月于上海长征医院和昆明医科大学第一附属医院皮肤科就诊的DPN和SK各20例患者的临床及组织病理资料进行回顾性分析总结。结果DPN发病年龄以中青年为主,SK发病年龄以中老年为主;DPN与SK患者性别构成比差异无统计学意义(P>0.05);DPN好发于面颈部、胸腹部,表现为米粒至绿豆大小、褐色扁平丘疹;SK好发于面颈部,表现为黄豆至钱币大小,深褐色、黑色斑疹,丘疹或斑丘疹,皮损表面粗糙,底部为圆形、椭圆形或不规则形,多数边界清楚。DPN患者的皮损组织病理特征与SK相似,以棘层肥厚型、角化过度型为主,SK组织病理分型有5型,以棘层肥厚型和疣状型为主。结论黑色丘疹性皮病是脂溢性角化病的一种亚型。

Objective To analyze the correlation between Dermatosis Papulosa Nigra(DPN)and Seborrheic Keratosis(SK)from the clinical,histopathology.Methods We collected 20 cases of dermatosis papulosa nigra and 20 cases of seborrheic keratosis admitted to the outpatient department of Shanghai Changzheng Hospital and First Affiliated Hospital of Kunming Medical University respectively from December 2018 to April 2020,and analyzed and summarized the clinical and histopathological data of all patients.Results DPN occurred in the middle-young age,while SK occurred in the mid-elderly.There was no statistically significant difference in gender composition of DPN and SK.DPN occurred in the face,neck,chest,and abdomen,and was characterized by millet to mung bean size,skin color,or brown papules.SK was most common in the face and neck.It is characterized by soybean-to-coin size,dark brown spots,papules or maculopapular rash.The surface of the lesion is rough,and the bottom is round,oval or irregular.Most of the boundaries are clear.Most of DPN type in the histopathology was hypertrophic,while acanthosis and verrucous in SK.Conclusion Dermatosis papulosanigra is a subtype of seborrheic keratosis.