重症脓毒血症患儿血乳酸水平及其与凝血功能异常的关系

Changes of Blood Lactate Levels in Children With Severe Sepsis and Its Correlation With Abnormal Blood Coagulation

目的对重症脓毒血症患儿血乳酸水平变化及其与凝血功能异常的关系进行研究。方法对我院在2017年2月—2019年5月收治的50例重症脓毒血症患儿进行研究(n=50),随机抽取同期非重症脓毒血症患儿50例作为对照组(n=50),分析两组患儿入院后不同时间点的血乳酸水平,分析两组患儿不同时间点的APTT、纤维蛋白原以及D-二聚体水平。结果重症组患儿入院后不同时间点的血乳酸水平均高于非重症组,有统计学意义(P<0.05);非重症组患儿治疗后APTT、纤维蛋白原以及D-二聚体水平均好于重症组,有统计学意义(P<0.05)。结论血乳酸水平是临床医护人员判断重症脓毒血症患儿疾病程度的重要性指标,这对于医护人员的后续临床治疗方案的拟定有着重大意义。

Objective To study the changes of blood lactate levels in children with severe sepsis and its relationship with abnormal blood coagulation.Methods Fifty children with severe sepsis treated in our hospital from February 2017 to May 2019 were studied(n=50).Fifty children with non-severe sepsis during the same period were randomly selected as the control group(n=50),the blood lactate levels at different time points after admission were analyzed,and APTT,fibrinogen,and D-dimer levels at different time points in the two groups were analyzed.Results The blood lactate levels of children in the severe group at different time points after admission were higher than those in the nonsevere group,which was statistically significant(P<0.05);the levels of APTT,fibrinogen,and D-dimer in the children in the non-severe group after treatment were statistically significant.Better than the severe group,with statistically significant(P<0.05).Conclusion Blood lactate level is an important indicator for clinical medical staff to judge the degree of disease in children with severe sepsis,which is of great significance for the development of subsequent clinical treatment plans for medical staff.