摘要
难治性高血压在临床上并不少见,其发生发展过程机制复杂,其中肾素-血管紧张素-醛固酮系统起重要作用。醛固酮是肾素-血管紧张素-醛固酮系统中的关键激素,对醛固酮具有拮抗作用的盐皮质激素受体拮抗剂是治疗难治性高血压的最佳药物选择之一。现主要对盐皮质激素受体拮抗剂在难治性高血压中的作用机制、相关临床研究及不良反应进行总结,以便临床医生更规范地使用该类药物。
Refractory hypertension(RHTN)is not uncommon in clinical practice.Among the complicated development mechanism of RHTN,renin-angiotensin-aldosterone system(RAAS)play an important role.Aldosterone is a key pivotal hormone in RAAS,as a result,mineralocorticoid receptor antagonist(MRAs),which has an antagonistic effect on aldosterone,is one of the best choice for treatment of RHTN.This review summarizes the mechanism,clinical studies and adverse reactions of MRAs in RHTN,and help physicians make better use of MRAs.
作者
汪羚利
李昭屏
WANG Lingli;LI Zhaoping(Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China)
出处
《心血管病学进展》
CAS
2020年第10期1026-1030,共5页
Advances in Cardiovascular Diseases
基金
重大新药创制科技重大专项(2017ZX 09304012-011)。
关键词
难治性高血压
盐皮质激素受体拮抗剂
螺内酯
依普利酮
Refractory hypertension
Mineralocorticoid receptor antagonists
Spironolactone,
Eplerenone
