扶正化瘀片联合替诺福韦酯治疗慢性乙型肝炎的临床研究

Clinical study on Fuzheng Huayu Tablets combined with tenofovir dipivoxil in treatment of chronic hepatitis B

目的探讨扶正化瘀片联合富马酸替诺福韦二吡呋酯片治疗慢性乙型肝炎患者的临床疗效。方法选取2018年7月—2020年1月天津市第三中心医院收治的240例慢性乙型肝炎患者作为研究对象,按照随机数字表法将所有患者分为对照组和治疗组,每组各120例。对照组口服富马酸替诺福韦二吡呋酯片,300 mg/次,1次/d。治疗组在对照组患者治疗的基础上口服扶正化瘀片,1.6 g/次,3次/d。两组患者连续治疗3个月。观察两组的临床疗效,比较两组辅助性T细胞17(Th17)细胞、调节性T细胞(Treg)细胞、Th17/Treg、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、白蛋白(ALB)、总胆红素(TBIL)水平。结果治疗后,治疗组患者的临床总有效率(95.83%)高于对照组(88.33%),差异有统计学意义(P<0.05)。治疗后,两组的ALT、AST、TBIL水平明显降低,ALB水平明显升高(P<0.05);治疗后治疗组的ALB水平比对照组高,ALT、AST、TBIL水平低于对照组(P<0.05)。治疗后,两组的Th17细胞、Treg细胞、Th17/Treg明显降低(P<0.05);治疗后治疗组的Th17细胞、Treg细胞、Th17/Treg低于对照组(P<0.05)。结论扶正化瘀片联合富马酸替诺福韦二吡呋酯片能提高慢性乙型肝炎的疗效,改善肝功能,降低Th17细胞、Treg细胞水平。

Objective To investigate the clinical effect of Fuzheng Huayu Tablets combined with Tenofovir Disoproxil Fumarate Tablets in treatment of chronic hepatitis B.Methods Patients(240 cases)with chronic hepatitis B in Tianjin Third Central Hospital from June 2018 to January 2020 were randomly divided into control and treatment groups,and each group had 120 cases.Patients in the control group were po administered with Tenofovir Disoproxil Fumarate Tablets,300 mg/time,once daily.Patients in the treatment group were po administered with Fuzheng Huayu Tablets on the basis of the control group,1.6 g/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical efficacies were evaluated,and Th17,Treg,Th17/Treg,the levels of ALT,AST,ALB,and TBIL in two groups were compared.Results After treatment,the clinical total effective rate of the treatment group(95.83%)was higher than that of the control group(88.33%),and the difference was statistically significant(P<0.05).After treatment,the levels of ALT,AST,and TBIL in two groups were significantly decreased,but the level of ALB was significantly increased(P<0.05).And after treatment,the level of ALB in the treatment group was higher than that in the control group,but the levels of ALT,AST,and TBIL in the treatment group were lower than those in the control group(P<0.05).After treatment,Th17 cells,Treg cells,and Th17/Treg of two groups were significantly decreased(P<0.05).After treatment,Th17 cells,Treg cells,and Th17/Treg in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Fuzheng Huayu Tablets combined with Tenofovir Disoproxil Fumarate Tablets can improve the curative effect of chronic hepatitis B,improve liver function,and reduce the level of Th17 cells and Treg cells.