异斯特维醇及其衍生物抗肿瘤活性研究进展

Progress on Antitumor Activity of Isosteviol and Derivatives

异斯特维醇是天然产物甜菊苷水解得到的四环二萜化合物,具有降血压、降血脂及抗肿瘤功效,尤其是通过D环、19位羧基结构修饰引入活性亚结构单元,其抗肿瘤活性显著提高,因而受到研究者的广泛关注。综述近年异斯特维醇及其衍生物的抗肿瘤活性研究进展,以期为此类化合物的抗肿瘤新药开发研究提供参考。

Tetracyclic diterpene isosteviol,obtained from the hydrolysis of a natural stevioside,shows the effects of antihypertension,antihyperlipidemia and antitumor.Especially,the antitumor activity of isosteviol derivatives with active substructural units,chemically synthesized by the modification of D-ring and 19-carboxyl group,is significantly improved.Thus,isosteviol has attracted an increasing attention.In this paper,the research progress on antitumor activity of isosteviol and its derivatives in recent years are reviewed so that they will provide benefitsfor the development of new antitumor drugs.