活血化瘀类中成药不良反应结果分析报告

Analysis Report on Adverse Reactions of Chinese Patent Medicines for Blood-activating and Stasis-Dissolving

目的观察分析活血化瘀类中成药不良反应结果。方法选取本院2018年2月至2019年2月收治的采取活血化瘀类中成药进行治疗并产生不良反应的患者30例为研究对象,比较患者给药途径结果,不良反应产生时间、类型、原因构成比。结果给药途径构成比直肠6.67%,皮肤13.33%,肌肉20.22%,静脉滴注26.67%,口服33.33%,依次提升。不良反应原因构成比无适应证20.00%,配伍禁忌6.67%,未遵医嘱23.33%,超剂量26.67%,给药途径无合理性16.67%,其他原因6.67%。不良反应类型构成比胸闷气短10.00%,皮疹6.67%,食欲不振23.33%,头痛13.33%,全身瘙痒6.67%,其他原因40.00%。不良反应用药构成比1h内最高是33.33%,≥1h<24h是26.67%,≥24h<72h是16.67%,≥72h<1个月是13.33%,≥1个月是10.00%。结论活血化瘀类中成药不良反应的产生原因较多,患者较易产生食欲不振、头痛等不良反应,服药初期不良反应风险较高,需制定全面预防措施,严格筛查处方,提供用药指导。

Objective To observe and analyze adverse reactions of Chinese patent medicines for blood-activating and stasisdissolving.Methods Thirty patients with adverse reactions who were treated with Chinese patent medicines for blood-activating and stasis-dissolving and were admitted to the hospital from February 2018 to February 2019 were enrolled as study objects.The constituent ratios of administration ways,adverse reactions of occurrence time,types and cause were compared between the two groups.Results In constituent ratios of administration ways,rectum,skin,muscle,intravenous drip and oral administration accounted for 6.67%,13.33%,20.22%,26.67%and 33.33%,respectively.In constituent ratios of adverse reactions causes,non-indications,incompatibility,not following doctors'advice,overdose,unreasonable administration ways and other reasons accounted for 20.00%,6.67%,23.33%,26.67%,16.67%and 6.67%,respectively.In constituent ratios of adverse reactions types,chest distress and short of breath,rash,inappetence,headache,systemic pruritus and other reasons accounted for 10.00%,6.67%,23.33%,13.33%,6.67%and 40.00%,respectively.In constituent ratios of adverse reactions time,shorter than 1h was the highest(33.33%),followed by 1h-24h,24h-72h,72h-1 month and not shorter than 1 month(26.67%,16.67%,13.33%,10.00%).Conclusion There are many adverse reactions causes in Chinese patent medicines for blood-activating and stasisdissolving.Patients are easily to be accompanied with adverse reactions such as inappetence and headache.During early medication,adverse reactions risk is relatively higher.It is necessary to formulate comprehensive prevention measures,strictly screen prescription and provide medication guidance.