苯磺酸左旋氨氯地平与缬沙坦对高血压患者脂质代谢和系统性应激的影响

Effects of Levamlodipine Besylateand Valsartan on Lipid Metabolism and Systemic Stress in Patients with Hypertension

目的探讨苯磺酸左旋氨氯地平联合缬沙坦对原发性高血压患者脂质代谢和系统性应激的影响。方法选择我院2017年9月~2018年12月收治的226例高血压患者作为研究对象,按照随机数字表法分为实验组和对照组,各113例。对照组采用苯磺酸左旋氨氯地平治疗,实验组在此基础上联合缬沙坦治疗,比较两组临床疗效、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇(TC)、甘油三酯(TG)、舒张压(DBP)、收缩压(SBP)、C反应蛋白(CRP)、纤维蛋白原(FIB)、全血高切粘度(HBV)、红细胞聚集指数(EAI)、全血低切粘度(LBV)及不良反应发生情况。结果实验组总有效率为93.81%,高于对照组的80.53%,差异有统计学意义(P<0.05);实验组HDL高于对照组,LDL、TC和TG水平低于对照组,差异有统计学意义(P<0.05);实验组SBP、DBP水平低于对照组,差异有统计学意义(P<0.05);实验组CRP、FIB、HBV、LBV和EAI水平均低于对照组,差异有统计学意义(P<0.05);实验组不良反应发生率为6.35%,低于对照组的20.63%,差异有统计学意义(P<0.05)。结论苯磺酸左旋氨氯地平联合缬沙坦治疗高血压效果显著,可有效改善患者脂质代谢与系统性应激水平,不良反应少,安全性高。

Objective To investigate the effect of levamlodipine besylate combined with valsartan on lipid metabolism and systemic stress in patients with essential hypertension.Methods A total of 226 hypertensive patients admitted to our hospital from September 2017 to December 2018 were selected as the research objects and were divided into experimental group and control group according to the random number table method,with 113 cases in each group.The control group was treated with levamlodipine besylate,and the experimental group was combined with valsartan on this basis.The clinical efficacy,low-density lipoprotein(LDL),high-density lipoprotein(HDL),and total cholesterol(TC)were compared between the two groups,triglycerides(TG),diastolic blood pressure(DBP),systolic blood pressure(SBP),C-reactive protein(CRP),fibrinogen(FIB),whole blood high shear viscosity(HBV),erythrocyte aggregation index(EAI),whole blood low shear viscosity(LBV)and adverse reactions.Results The total effective rate of the experimental group was 93.81%,which was higher than 80.53%of the control group,the difference was statistically significant(P<0.05);The HDL of the experimental group was higher than that of the control group,and the levels of LDL,TC and TG were lower than the control group,the difference was statistically significant(P<0.05);the levels of SBP and DBP of the experimental group were lower than the control group,the difference was statistically significant(P<0.05);CRP,FIB,HBV,LBV and EAI levels of the experimental group were lower than those of the control group,the difference was statistically significant(P<0.05);the adverse reaction rate of the experimental group was 6.35%,which was lower than 20.63%of the control group,the difference was statistically significant(P<0.05).Conclusion The combination of levamlodipine besylate and valsartan had a significant effect in the treatment of hypertension,which could effectively improve the lipid metabolism and systemic stress level of patients with few adverse reactions and high safety.