阿奇霉素联合雾化治疗小儿支原体感染疗效

Efficacy of Azithromycin combined with atomization in the treatment of mycoplasma infection in children

目的探讨阿奇霉素联合雾化治疗小儿支原体感染的临床疗效。方法从天津市公安医院2018年4月-2019年7月收治的小儿支原体感染患儿中选取86例开展研究,随机分为对照组和观察组各43例,对照组患儿给予红霉素治疗,观察组患儿给予阿奇霉素联合雾化治疗,比较两组患儿的治疗有效率、临床症状消失时间、肺功能指标以及不良反应发生率。结果观察组患儿的总有效率为95.35%,高于对照组的79.07%;观察组患儿的咳嗽咳痰、发热、气喘以及干性湿啰音症状消失时间均短于对照组;治疗后观察组患儿的最大呼吸中段流速为(2.76±0.25)L/s,高于对照组的(1.10±0.16)L/s;观察组患儿的不良反应发生率为6.98%,低于对照组的20.93%,差异均有统计学意义(P<0.05)。结论对小儿支原体感染患儿采用阿奇霉素联合雾化治疗可以获得更好的治疗效果,值得临床推广应用。

Objective To explore the clinical effect of Azithromycin combined with atomization in the treatment of mycoplasma infection in children.Methods From April 2018 to July 2019,86 children with mycoplasma infection admitted to Tianjin Public Security Hospital were selected and randomly divided into control group and observation group with 43 cases in each group.The control group was treated with Erythromycin,while the observation group was given Azithromycin combined with atomization treatment.The treatment efficiency,clinical symptom disappearance time,pulmonary function index and incidence of adverse reactions were compared between the two group.Results The total effective rate of observation group was 95.35%,higher than 79.07%of control group;the disappearance time of cough,expectoration,fever,asthma and dry rales in the observation group were shorter than those in the control group;after treatment,the maximum middle respiratory velocity of the observation group was(2.76±0.25)L/s,which was higher than that of the control group with(1.10±0.16)L/s;the incidence of adverse reactions in the observation group was 6.98%,lower than 20.93%in the control group,and the differences above all were statistically significant(P<0.05).Conclusion Azithromycin combined with atomization treatment could obtain better therapeutic effect on children with mycoplasma infection,which was worthy of clinical promotion and application.