外泌体miRNA在非小细胞肺癌中的潜在临床意义

Potential clinical significance of exosome miRNA in non-small cell lung cancer

外泌体是大多数细胞分泌的一类细胞外囊泡,是运输生物分子以促进细胞间通讯的纳米级天然载体,具有提供诊断和治疗的巨大潜力。微小RNA(miRNA)是一种小的非编码RNA基因,在多种类型的癌症中异常表达,在人类癌症发病机制中有着重要的作用,在一定程度上反映出供体细胞的分子改变,具有一定的诊断及潜在的治疗价值。文章讨论不同生物体液的多种外泌体miRNA在非小细胞肺癌诊治中的潜在临床意义。

Exosome is a kind of extracellular vesicles secreted by most cells,and is a nanometre natural carrier that can transport biomolecules to promote intercellular communication with the huge potential of diagnosis and treatment.microRNA(miRNA)is a small non-coding RNA gene,which is abnormally expressed in many types of cancer and plays an important role in the pathogenesis of cancer.miRNA can also reflect molecular changes in donor cells.Therefore,extracellular miRNA can be potentially used for diagnosis and therapeutics.This review focuses on the potential clinical significance of exosome miRNA in biological fluids for the diagnosis of non-small cell lung cancer.