替诺福韦联合复方甘草酸苷治疗乙型肝炎肝硬化的效果观察

Efficacy of tenofovir combined with compound glycyrrhizin in the treatment of hepatitis B cirrhosis

目的:探讨并研究用替诺福韦联合复方甘草酸苷治疗乙型病毒性肝炎(乙型肝炎)肝硬化的效果。方法:选择近年来绵阳市中心医院收治的84例乙型肝炎肝硬化患者作为研究对象。随机将其分为研究组(n=42)与对照组(n=42)。对两组患者均进行常规治疗,在此基础上用替诺福韦对对照组患者进行治疗,用替诺福韦联合复方甘草酸苷对研究组患者进行治疗,然后比较两组患者的疗效及各项临床指标。结果:治疗24周后,研究组患者血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和转化生长因子-β1(TGF-β1)的水平均低于对照组患者,差异有统计学意义(P<0.05)。治疗24周后,研究组患者血清乙肝病毒脱氧核糖核酸(HBV-DNA)的水平低于对照组患者,其HBV-DNA的转阴率高于对照组患者,差异有统计学意义(P<0.05)。研究组患者治疗的总有效率高于对照组患者,差异有统计学意义(P<0.05)。结论:用替诺福韦联合复方甘草酸苷治疗乙型肝炎肝硬化的效果显著,能有效地改善患者的肝功能,降低其血清炎性细胞因子的水平,提高其HBV-DNA的转阴率。

Objective:To explore and study the effect of tenofovir combined with compound glycyrrhizin in the treatment of liver cirrhosis with viral hepatitis B(HEPATITIS B).Methods:84 patients with hepatitis B cirrhosis admitted to Mianyang Central Hospital in recent years were selected as the research objects.They were randomly divided into study group(n=42)and control group(n=42).The two groups of patients were routinely treated,on the basis of tenofovir treatment for the control group,tenofovir treatment combined with compound glycyrrhizin treatment for the study group,and then compared the two groups of patients efficacy and various clinical indicators.Results:After 24 weeks of treatment,the serum levels of ALT,AST,TBIL,IL-6,TNF-αand TGF-β1 in the study group were all lower than those in the control group,and the differences were statistically significant(P<0.05).After 24 weeks of treatment,the hbV-DNA level in the study group was lower than that in the control group,and the hbV-DNA negative conversion rate was higher than that in the control group,with statistically significant difference(P<0.05).The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Tenofovir combined with compound glycyrrhizin in the treatment of hepatitis B cirrhosis has a significant effect,which can effectively improve the liver function of patients,reduce the level of serum inflammatory cytokines,and increase the negative conversion rate of HBV-DNA.