摘要
骨髓间充质干细胞是一类具有多项分化潜能的干细胞,在一定条件下可以向成骨细胞分化。而骨髓间充质干细胞成骨分化是多基因、多步骤的复杂过程,多种信号通路如Wnt/β-catenin、BMP/Smad、PI3K/Akt均参与其中,靶向研究相关信号通路及其关联基因是目前解决以骨质疏松、骨折修复为代表的骨组织工程问题的关键。本文参考骨髓间充质干细胞成骨分化相关基因及信号通路的有关文献,将最新研究进展作一综述,旨在为骨组织工程的研究及应用提供新策略。
Bone marrow mesenchymal stem cells are a type of stem cells with multiple differentiation potentials,which can differentiate into osteoblasts under certain conditions.The osteogenic differentiation of bone marrow mesenchy-mal stem cells are multi-gene,multi-step process.A variety of signaling pathways such as Wnt/β-catenin,BMP/Smad,PI3K/Akt,and so on are involved.Targeted research on related signaling pathways and their associations genes are the key to solve bone tissue engineering problems represented by osteoporosis and fracture repair.In this paper,we refer to genes and signaling pathways related to osteogenic differentiation of bone marrow mesenchymal stem cells in the past five years,and summarize the latest research progress in order to provide new strategies for the research and application of bone tissue engineering.
作者
姜朝阳
谢兴文
徐世红
李鼎鹏
柳博
林德民
JIANG Zhao-yang;XIE Xing-wen;XU Shi-hong;LI Ding-peng;LIU Bo;LIN De-min(Gansu University of Traditional Chinese Medicine,Clinical College of Chinese Medicine,Lanzhou 730000, China;Department of Orthopedics,the Second People's Hospital of Gansu Provincial,Lanzhou 730000, China;Department of Orthopedics,Affiliated Hospital of Northwest Minzu University,Lanzhou 730000, China;Trauma Center,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000, China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
北大核心
2020年第5期473-478,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然基金地区项目(81860864)。
关键词
骨髓间充质干细胞
成骨细胞
信号通路
基因
因子
bone marrow mesenchymal stem cells
osteoblasts
signaling pathways
genes
factors
