X连锁显性低血磷性佝偻病并发甲状旁腺功能亢进症

Hyperparathyroidism in X-linked hypophosphatemia

X连锁显性低血磷性佝偻病/骨软化症患者常并发甲状旁腺素升高,一部分与中性磷治疗相关,一部分未治疗患者即可发现继发性甲状旁腺功能亢进症,甲状旁腺素升高可进一步加重肾脏失磷,甚至引起高血压、心脏钙化等问题,增加治疗难度,影响患者生存质量,进展为三发性甲旁亢时则使治疗变得更为复杂,因此纠正或预防甲状旁腺功能亢进是X连锁显性遗传低血磷性佝偻病慢性病治疗和管理的重要部分。本文对这一并发症的临床特征、可能机制及治疗进行综述。

Hyperparathyroidism was frequently reported in patients diagnosised with X-linked Hypophosphate-mia,some of which is related to the treatment of oral phosphorus,whereas some of the untreated patients can also be complicated by this condition.Increasing parathyroid hormone can further aggravate renal phosphate wasting and is related to hypertension,cardiac calcification and so on.This complication not only increase the difficulty of treatment,but also affect the quality of life,especially when progressing to the teritary hyperparathyroidism.The management of parathyroid hormone is an important part of XLH treatment.This article reviews the clinical features,possible mechanisms,and treatment of this comorbidity.