《中医方剂大辞典》治疗不孕症方剂用药规律挖掘研究

Data mining on the rules of prescription in the treatment of infertility(female)in Dictionary of Traditional Chinese Medicine Prescriptions

目的分析《中医方剂大辞典》治疗不孕症方剂的组方配伍规律。方法收集《中医方剂大辞典》中治疗不孕症的内服方剂,采用中医传承辅助系统(V2.5)的关联规则分析、改进的互信息法、复杂系统熵聚类及无监督的熵层次聚类等方法进行分析。结果共收集明确治疗不孕症的内服处方302首,涉及中药352味,药性以温性为主,药味以甘味多见,其次是辛、苦二味,主要归肝、脾、肾、心经,使用频次>30次的有37味,排名前十的分别是当归、川芎、茯苓、熟地黄、白芍、人参、香附、白术、肉桂、生地黄;频次>60次的常用药物组合40个,排名前四的分别是当归-川芎、当归-白芍、熟地黄-当归、川芎-白芍;复杂系统熵聚类得到3~5味药的核心组合13组,进一步聚类形成13个新方。结论《中医方剂大辞典》中治疗不孕症的方剂用药以调补气血、滋养五脏为主,适当配以理气开郁、燥湿化痰、温经通滞之品。

Objective To analyze the compatibility of prescriptions for infertility(female)in the Dictionary of Traditional Chinese Medicine Prescriptions.Methods The prescriptions for infertility(female)in the Dictionary of Traditional Chinese Medicine Prescriptions were collected and analyzed by association rules analysis,mutual information method,complex system entropy clustering and unsupervised entropy hierarchical clustering with the Traditional Chinese Medicine Inheritance Support System(v2.5).Results A total of 302 prescriptions were collected for the treatment of infertility(female),involving 352 kinds of traditional Chinese medicine,with warm nature as the main property and sweet taste as the main flavor,followed by pungent and bitter flavor,mainly belonging to liver,spleen,kidney and heart meridian.Thirty seven prescriptions were used more than 30 times,and the top ten were Angelicae sinensis radix,Chuanxiong rhizoma,Pori a,Rehtnanniae radix praeparata,Paeon iae radix alba,Ginseng radix et rhizoma,Cyperi rhizoma,Atractylodis macrocephalae rhizoma,Cinnamomi cortex and Rehmanniae radix.There were 40 common drug combinations for 60 times,the top four including Angelicae sinensis radix-Chuanxiong rhizoma,Angelicae sinensis radix-Paeoniae radix alba,Rehmanniae radix praeparata-Angelicae sinensis radix and Chuanxiong rhizoma-Paeoniae radix alba.Thirteen core combinations of 3-5 herbs were obtained by complex system entropy clustering,and 13 new prescriptions were formed by further clustering.Conclusions According to the Dictionary of Traditional Chinese Medicine Prescriptions,prescriptions for infertility(female)are mainly used to regulate qi and blood,nourish the five zang organs,and properly matching with those for regulating qi to open depression,drying dampness to dissipate phlegm,and warming meridians to dredge stagnation.