茯苓多糖及其衍生物的化学结构与药理作用研究进展

Research progress on chemical structures and pharmacological activities of Poria cocos polysaccharide and its derivatives

茯苓为国家药食同源中药材品种,具有利水渗湿、健脾宁心等功效。茯苓多糖作为其中最主要的活性物质之一,药理研究表明其具有调节机体免疫力、抗炎、抗氧化、抗肿瘤、保肝等药理活性,存在巨大的开发利用价值。该文通过查阅相关文献,系统总结茯苓多糖及其衍生物的化学结构及近年来对其药理作用的研究进展,全面深入探讨茯苓多糖的化学组成和活性,讨论当前存在问题,为深入探究茯苓多糖构效关系以及进一步开发利用提供参考。

Poria cocos is a both medicinal and edible Chinese herb variety,with the effects of diuretic,spleen-enhancing and tranquilizing.P.cocos polysaccharide(PCP)is one of the most important active substances of P.cocos.Pharmacological research shows that PCP has a variety of pharmacological activities such as regulating immunity,anti-inflammatory,anti-oxidation,antitumor,and liver protection,with a huge development and utilization value.By consulting the relevant literature,we systematically summarized the chemical structures and the research progress on pharmacological activities of PCP and its derivatives in recent years to explore the chemical compositions and activities of PCP thoroughly.In addition,the current problems were discussed in this article to provide reference for further exploration of the structure-activity relationship of PCP and its further development and utilization.