基于数据可视化的中医治疗劳累性心绞痛的中药药性及证-症-方-药网络研究

Study on drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine in treatment of effort angina pectoris based on data visualization

该文采用数据可视化技术探讨中医治疗劳累性心绞痛的中药药性及证-症-方-药网络,为临床诊疗提供有益参考。检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(WanFang)、维普期刊资源整合服务平台(VIP)及中国生物医学文献数据库(CBM)建库至2019年8月31日发表的所有采用中医方剂治疗劳累性心绞痛的文献,规范证候、症状、方剂、中药名称并建立相应数据库,分析药物频次、四气、五味与归经,采用生物信息分析法构建可视化证-症-方-药网络关系。结果共纳入方剂202首,涉及中药218味,使用频次≥10的中药56味,证型78个,症状162项。中医治疗该病主要以活血化瘀药、补虚药、理气药、化痰止咳平喘药、解表药、清热药等组方;药性主要为温性、寒性、平性药,占95%;药味主要为甘味、苦味、辛味药,占89%;主要归脾、心、肝、肺、胃、肾经,占89%。成功构建了中医治疗该病的证-症-方-药网络,表明该病的中医证候以气虚血瘀证、气滞血瘀证、心血瘀阻证、痰瘀互结证频次较高,症状以胸闷、胸痛、心悸、气短、神疲乏力、舌紫暗、自汗、痰多等频次较高,方剂以血府逐瘀汤、瓜蒌薤白半夏汤、丹参饮、桃红四物汤、生脉散、补阳还五汤、炙甘草汤为高频核心进行组方,组方的核心药物包括丹参、黄芪、川芎、人参、瓜蒌、薤白、三七、桃仁、红花、白术、当归、赤芍、茯苓、法半夏等。中医治疗该病的中药药性及证-症-方-药网络能够实现数据可视化,可用于客观反映临床辨证分型及遣方用药规律,为临床诊治提供参考。

This article aims to explore drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine(TCM)in the treatment of effort angina pectoris based on data visualization,and provide useful references for clinical diagnosis and treatment.Literatures about TCM formula for effort angina pectoris from databases of CNKI,WanFang,VIP,and CBM were retrieved from the database-building to August 31,2019.The name of syndromes,symptoms,formulas,and herbs were standardized,and the corresponding databases were established.Frequency,four properties,five flavors,and meridian were analyzed.Visualized syndrome-symptom-formula-herb network relationships were constructed by bioinformatic analysis.A total of 202 formulas were included,and 218 kinds of TCM were involved.There were 56 herbs with the use frequency of more than 10,involving 78 syndromes and 162 symptoms.TCM formulas in the treatment of effort angina pectoris mainly included herbs with effects in invigorating blood circulation and eliminating stasis,tonifying deficiency,Qi-regulating,resolving phlegm and relieving cough and asthma,relieving exterior disorder,and heat-clearing.The main properties were warm,cold and mild(accounting for 95%);the main flavors were sweet,bitter and pungent(accounting for 89%);and meridians were mainly spleen,heart,liver,lung,stomach,and kidney(accounting for 89%).Syndrome-symptom-formula-herb network of TCM in the treatment of effort angina pectoris were successfully constructed.The high-frequency syndromes of this disease were Qi deficiency and blood stasis,Qi stagnation and blood stasis,heart blood stasis,and turbid phlegm and blood stasis,and its high-frequency symptoms were chest tightness,chest pain,palpitation,shortness of breath,fatigue,dark purple tongue,spontaneous sweating,and abundant phlegm.High-frequency core formulas of this disease included Xuefu Zhuyu Decoction,Gualou Xiebai Banxia Decoction,Danshen Decoction,Taohong Siwu Decoction,Shengmai Powder,Buyang Huanwu Decoction and Zhigancao Decoction,and their core herbs included Salviae Miltiorrhizae Radix et Rhizoma,Astragali Radix,Chuanxiong Rhizoma,Ginseng Radix et Rhizoma,Trichosanthis Fructus,Allium Macrostemonis Bulbus,Notoginseng Radix et Rhizoma,Persicae Semen,Carthami Flos,Atractylodis Macrocephalae Rhizoma,Angelicae Sinensis Radix,Paeoniae Radix Rubra,Poria,Pinelliae Rhizoma Praeparatum.Drug properties and syndrome-symptom-formula-herb networks of TCM in the treatment of effort angina pectoris can realize data visualization,objectively reflect the clinical syndrome differentiation and rule of medication,and provide reference for clinical diagnosis and treatment.