A型肉毒素联合普瑞巴林治疗带状疱疹后遗神经痛的临床疗效

Clinical effect of Botulinum toxin type A combined with pregabalin in the treatment of postherpetic neuralgia

目的探讨A型肉毒素联合普瑞巴林治疗带状疱疹后遗神经痛(PHN)的临床疗效。方法选取江门市新会区第二人民医院2014年5月—2018年10月收治的PHN患者110例,随机分为对照组与观察组,各55例。对照组予以普瑞巴林胶囊治疗,观察组在对照组基础上予以A型肉毒素治疗。两组均治疗8周。比较两组临床疗效、治疗前后视觉模拟评分法(VAS)评分与β-内啡肽(β-EP)水平,并观察两组不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗前两组VAS评分与β-EP水平比较,差异无统计学意义(P>0.05);治疗后观察组VAS评分低于对照组,β-EP水平高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论A型肉毒素联合普瑞巴林胶囊治疗PHN的临床疗效确切,可有效缓解患者疼痛,且安全性较高。

Objective To discuss clinical effect of Botulinum toxin type A combined with pregabalin in the treatment of postherpetic neuralgia(PHN).Methods A total of 110 cases of patients with PHN were selected from May 2014 to October 2018 in the Second People's Hospital of Xinhui District Jiangmen City,which were randomly divided into control group and observation group,55 cases in each group.The control group was treated with pregabalin capsule,and the observation group was treated with botulinum toxin A on the basis of the control group.Both groups were treated for 8 weeks.Clinical effect,Visual analogue score(VAS)andβ-EP before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of the observation group was higher than control group(P<0.05).Before treatment,there was no significant difference in VAS score andβ-EP between the two groups(P>0.05);after treatment,the observation group of VAS score was lower than control group,andβ-EP was higher than control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Botulinum toxin type A combined with pregabalin have an exact clinical effect for PHN,which can effectively relieve the pain of patients,and with high safety.