多糖的新型制剂研究进展

Research progress of novel preparations of polysaccharides

多糖是由多个单糖或单糖衍生物连接而成的高分子化合物,具有多种生物活性,如抗肿瘤、抗氧化、抗病毒、增强免疫力、降血糖以及降血脂等,其结构的复杂性,生物活性的多样性,良好的应用前景和广阔的来源,吸引了大量科研工作者投入其中。将微囊和微球、纳米粒、脂质体等制剂新技术用于多糖的制剂研究与开发,不仅有利于提高多糖药物的稳定性、生物利用度,而且在疾病治疗中具有靶向性好、生物相容性高等优势。该文对多糖药物的特性进行了阐述,在此基础上综述了多糖新剂型的研究进展,概述了多糖新剂型的适用范围,以期为天然药物多糖新剂型的开发与应用研究提供参考。

Polysaccharides are macromolecular compounds linked by multiple monosaccharides or monosaccharide derivatives,with a variety of biological activities,such as anti-tumor,anti-oxidation,anti-virus,immunity enhancement,hypoglycemic,hypolipidemic.Its complex structure,diverse biological activities,good application prospects and broad sources of polysaccharides have attracted more and more researchers.The application of microcapsules,microspheres,nanoparticles,liposomes and other new preparation techniques in the preparation research and development of polysaccharides will not only improve the stability and bioavailability of polysaccharides,but also have a good targeting in the treatment of diseases and high biocompatibility.This paper described the characteristics of polysaccharide drugs,reviewed the research progress of new polysaccharide dosage forms,and summarized the application scope of new polysaccharide dosage forms,in order to provide new reference for the development and application of polysaccharides.