巨噬细胞在急性胰腺炎中的作用研究进展

The role of macrophages in acute pancreatitis

急性胰腺炎(acute pancreatitis,AP)一种常见且严重的、可致全身多器官功能障碍的疾病。随着对AP发病机制研究的不断深入,近年来的研究发现巨噬细胞在AP的始动和进展中发挥重要作用。全身固有巨噬细胞群,如胰腺巨噬细胞、肝脏Kupffer细胞、腹膜巨噬细胞、肺巨噬细胞等,能在胰腺炎的不同阶段被炎症介质所激活,触发炎症级联反应,引起全身炎症反应综合征。本文就巨噬细胞在AP中作用机制的研究进展作一综述。

Acute pancreatitis(AP)is a common and severe disease causing multiple organ dysfunction.With the deepening of research on AP pathogenesis,it has been found that macrophages play an important role in the initiation and progress of AP.The systemic innate macrophage populations,such as the pancreatic macrophages,Kupffer cells,peritoneal macrophages and pulmonary macrophages,can be activated by inflammatory mediators in different stages of pancreatitis,triggering inflammatory cascade reaction and systemic inflammatory response syndrome.This review focused on the recent progress in the role of macrophages in AP.