线粒体相关内质网膜与病原体诱导的炎症反应研究进展

Research progress in the relationship between the mitochondria-associated membranes and pathogen-induced inflammatory response

线粒体相关内质网膜(mitochondria-associated membranes,MAMs)是内质网和线粒体外膜通过蛋白质连接组成的一个高度特化亚细胞区,许多蛋白质通过定位或招募到MAMs参与钙稳态维持、细胞凋亡、脂质合成与利用、细胞自噬等重要细胞事件,并为抗病毒信号转导和NOD样受体蛋白3(NLRP3)炎症小体组装提供平台。鉴于这些功能,MAMs在抵抗病原体感染中发挥重要作用,而病原体也进化出不同策略,靶向MAMs以逃避或拮抗宿主免疫应答,或通过调控MAMs功能为感染建立提供便利。病原体感染是引起炎症反应最常见的原因,急性炎症反应失调常引起一系列慢性炎症性疾病。本文将对MAMs功能与病原体诱导的炎症反应之间联系作一综述。

Mitochondria-associated membranes(MAMs)are highly specialized subcellular regions composed of the endoplasmic reticulum and mitochondrial outer membrane connected by proteins.They participate in several important cell events such as calcium homeostasis maintenance,cell apoptosis,lipid synthesis and utilization,and cell autophagy,and also provide a platform for antiviral signal transduction and Nod-like receptor protein-3(NLRP3)inflammasome assembly.Thus,MAMs play an important role in resisting pathogen infection.However,pathogens have evolved different coping strategies such as targeting MAMs to escape or antagonize host immune response,or regulating the functions of MAMs to facilitate infection.The most common reason of inflammatory response is pathogen infection.The disorder of acute inflammatory response usually leads to a series of chronic inflammatory diseases.This review summarized the relationship between the functions of MAMs and pathogen-induced inflammatory response.