亚低温治疗过程中缺氧缺血性脑病新生儿脑血流动力学改变及近红外光谱监测的意义

Hemodynamic changes and the significance of near-infrared spectroscopy monitoring in neonatal hypoxic-ischemic encephalopathy during mild hypothermia treatment

为了改善亚低温治疗效果、尽量减少亚低温对脑血流动力学的负面影响和改善缺氧缺血性脑病患儿的预后,需要进一步探讨在亚低温治疗情况下缺氧缺血性脑病患儿的脑血流动力学紊乱机制,全身血流动力学改变对脑血流的影响,以及如何利用近红外光谱技术监测脑血流并调整血管活性药物使用剂量,以改善亚低温和复温过程中的脑血流波动,帮助患儿平稳渡过亚低温和复温阶段。

To improve the therapeutic effect of mild hypothermia,avoid the adverse impact of mild hypothermia on cerebral blood flow,and improve the prognosis of hypoxic-ischemic encephalopathy,it is necessary to further explore the mechanism of cerebral hemodynamic disorder in hypoxic-ischemic encephalopathy under mild hypothermia treatment,the influence of systemic hemodynamic changes on cerebral blood flow,and the use of near-infrared spectroscopy to monitor cerebral blood flow and adjust the dosage of vasoactive drugs for avoiding large fluctuation of cerebral blood flow during mild hypothermia treatment and rewarming.