草甘膦农药对斑马鱼的急性毒性和慢性毒性研究

Study on Acute and Chronic Toxicity of Glyphosate to Zebrafish

草甘膦是目前世界上用量最大的除草剂。本文以斑马鱼作为模式生物,研究有机磷农药对斑马鱼的急性毒性以及慢性毒性的影响。急性毒性结果表明,草甘膦96hLC50为0.879 ppm,依照毒性分类标准属于高毒农药。慢性毒性表明,随着草甘膦农药浓度的增加,乙酰胆碱酯酶的活性会持续降低。农业中草甘膦使用不当,随着生物富集效应,草甘膦对人类健康和生态环境有潜在危害。该实验结果可以为当地的农药用量管控提供重要的参考价值。

Glyphosate is the most widely used herbicide in the world.Zebrafish was used as a model organism to determine the acute and chronic toxicity of glyphosate.The results showed that glyphosate 96hlC 50 was 0.879 ppm,which was a highly toxic pesticide.Chronic toxicity showed that the activity of acetylcholinesterase decreased with the increase of glyphosate concentration.The improper use of glyphosate in agriculture,with the bioaccumulation effect,was potential damage to human health and ecological environment.The results of this experiment can provide vital reference value for local pesticide dosage control.