摘要
糖尿病性白内障是一类由糖尿病引起或加重的眼部并发症,其发生发展很大程度上受糖尿病的影响,故对其发病机制及药物治疗的研究至关重要。文中着重列举并分析了当前对糖尿病白内障发病机制的各项研究方法及结果,包含信号通路途径、炎性介质影响、相关基因改变、外泌体及非编码RNA的作用等多个方面。同时,还阐述了糖尿病白内障在药物治疗研究方面的进展与不足。
Diabetic cataract is one of the ocular complications caused or aggravated by diabetes mellitus,and the incidence and progression of diabetic cataract is significantly affected by diabetes mellitus.Consequently,it is of significance to investigate the pathogenesis and medical treatment of diabetic cataract.In this article,study methods and outcomes of the pathogenesis of diabetic cataract were reviewed including signaling pathway,influence of inflammatory mediators,variations of related genes,and effect of exosomes and non-coding RNAs.In addition,the research progress and limitations on the drug therapy of diabetic cataract were summarized.
作者
高潮
吴继红(综述)
罗怡(审校)
GAO Chao;WU Jihong;LUO Yi(Eye&ENT Hospital of Fudan University,Shanghai 200031;NHC Key Laboratory of Myopia,Shanghai 200031;Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai 200031,China)
出处
《眼科学报》
2020年第4期234-242,共9页
Eye Science
基金
国家自然科学基金(81870645)。
