银杏达莫注射液联合氟哌噻吨美利曲辛对急性缺血性脑卒中后抑郁患者抑郁量表评分及复发率的影响

Efficacy of GLEDI plus flupentixol-melitracen on HAMD-17 score and recurrence in patients with depression after acute ischemic stroke

目的:探究银杏达莫注射液联合氟哌噻吨美利曲辛对急性缺血性脑卒中后抑郁患者的价值。方法:选取我院2017年10月-2019年1月急性缺血性脑卒中后抑郁患者92例,根据治疗方案不同均分为研究组(46例)、参照组(46例),两组均给予常规缺血性脑卒中治疗,参照组在常规治疗的基础上给予氟哌噻吨美利曲辛,研究组在参照组的基础上给予银杏达莫注射液,比较两组治疗效果、治疗前后汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD-17)、抑郁自评量表(Self-Rating Depression Scale,SDS)、日常生活能力(Activity of Daily Living,ADL)、复发率。结果:研究组治疗总有效率高于参照组(P<0.05);治疗后两组HAMD-17、SDS评分均有所降低,且研究组低于参照组(P<0.05);治疗后两组血浆黏度(Plasma Viscosity,PV)、纤维蛋白原(Fibrinogen,FIB)、血小板聚集率(Platelet Aggregation Rate,PAR)均有所降低,且研究组低于参照组(P<0.05);治疗后两组ADL评分均有所提高,且研究组高于参照组(P<0.05);研究组之后3个月复发率及累计复发率低于参照组(P<0.05)。结论:银杏达莫注射液联合氟哌噻吨美利曲辛治疗急性缺血性脑卒中后抑郁患者效果确切,可有效改善抑郁症状,调节血液流变学,增强日常生活能力,降低脑卒中复发率。

Objective:To explore clinical effect of ginkgo leaf extact and dipyridamole injection(GLEDI)plus flupentixol-melitracen on depression after acute ischemic stroke.Methods:92 patients with depression after acute ischemic stroke were divided into the study group and the control group.The control group was given conventional treatment and flupentixol-melitracen.The study group was given GLEDI more.Results:The efficiency in the study group was higher than that in the control group(P<0.05).After treatment,HAMD-17 and SDS scores in both groups were decreased,and those in the study group was lower(P<0.05).After treatment,PV,FIB,PAR in groups were decreased,and those in the study group were lower(P<0.05).After treatment,the ADL score in groups was improved,and this in the study group was higher(P<0.05).The recurrence and cumulative recurrence in the study group in 3 months were lower than those in the control group(P<0.05).Conclusion:GLEDI plus flupentixol-melitracen was effective on depression after acute ischemic stroke,can effectively improve the symptoms of depression,regulate hemorheology,enhance the ability of daily life,and reduce the recurrence of stroke.