肥厚型心肌病预后因素的研究进展

Advances in prognostic factors of hypertrophic cardiomyopathy

肥厚型心肌病(hypertrophic cardio myopathy,HCM)是一种常染色体显性遗传性的原发性心肌病,其特征是在没有任何心脏或系统疾病的情况下,左心室肥大、心肌细胞肥大和不规则,以及间质纤维化,是导致青少年和运动员猝死的最主要原因之一。肥厚型心肌病的预后具有很大的差异性,左心室流出道梗阻、心房肥大等影响因素可增加肥厚型心肌病的心血管不良事件的发生率,可以早期对肥厚型心肌病患者进行危险分层,及时给予有效的干预措施,改善患者的预后。本文就肥厚型心肌病预后影响因素的最新研究进展予以综述,为肥厚型心肌病的治疗及管理提供参考。

Hypertrophic cardiomyopathy(HCM)is an autosomal dominant primary cardiomyopathy,characterized by left ventricular hypertrophy,cardiomyocyte hypertrophy and irregularity,and interstitial fibrosis in the absence of any cardiac or systemic disease.It is one of the leading causes of sudden death in adolescents and athletes.The prognosis of hypertrophic cardiomyopathy varies greatly.Factors such as left ventricular outflow tract obstruction and atrial hypertrophy can increase the incidence of cardiovascular adverse events in hypertrophic cardiomyopathy.The risk stratification of hypertrophic cardiomyopathy can be carried out earlier,and effective intervention measures can be given in time to improve the prognosis of patients.This article reviews the latest research progress on the factors influencing the prognosis of hypertrophic cardiomyopathy,and provides references for the treatment and management of hypertrophic cardiomyopathy.