Dock2调节免疫细胞功能的研究进展

Research progress of Dock2 in regulating immune cell function

细胞分裂贡献者2(Dock2)能通过激活下游小G蛋白Rac,参与免疫细胞的发育、活化、增殖、细胞迁移和效应等重要生理过程,然而Dock2在各种免疫细胞的主要功能存在差异。Dock2调控T、B淋巴细胞的发育、活化、迁移;调控NK细胞的细胞毒性、脱颗粒和IFN-γ的分泌;调控中性粒细胞的趋化、活性氧(ROS)的产生和胞外杀菌网络(NETs)的形成;Dock2还参与了浆细胞样树突状细胞(pDCs)中Ⅰ型IFNs的产生。本文总结了以往关于Dock2在免疫细胞的各方面功能研究,期望有助于理解Dock2在各种免疫相关性疾病的发生发展中的重要性。

Dedicator of cytokinesis 2(Dock2)is important in the development,activation,proliferation,cell migration,effects and other important physiological processes of immune cells. However,the main functions of Dock2 in various cells are inconsistent. Dock2 promotes the development,activation and migration of T and B lymphocytes by activated Rac,and regulates the cytotoxicity,degranulation and IFN-γ secretion of NK cells;Dock2 regulates neutrophil chemotaxis,ROS production and NETs formation. Dock2 also participates in the production of type Ⅰ IFNs in plasmacytoid dendritic cells(pDCs). This paper summarizes the previous studies on the function of Dock2 in various aspects of immune cells,facilitating the understanding on the significance of Dock2 in different immune-related diseases.