α-卤代腙与α-异氰酸酯反应合成4-腙基-2-异氰基丁酸酯类化合物

The Reaction ofα-Halo Hydrazones andα-Isocyano Esters to Access 4-Hydrazineylidene-2-isocyanobutanoates

α-卤代腙与α-异氰酸酯在三乙胺作用下反应,生成4-腙基-2-异氰基丁酸酯类化合物。通过优化合成工艺,确定最佳反应条件为:α-卤代腙(1.0 eq.),α-异氰酸酯(1.2 eq.),三乙胺(1.2 eq.),二氯甲烷作溶剂,反应24 h。在此条件下进行了底物普适性研究,以高达79%的收率得到一系列具有潜在价值的4-腙基-2-异氰基丁酸酯类化合物,产物结构经1H NMR,13C NMR和MS(ESI)确证。

A series of 4-hydrazineylidene-2-isocyanobutanoates with potential values were obtained in up to 79%yield by the reactions ofα-isocyano esters withα-halo hydrazones.The optimal conditions were confirmed:α-halo hydrazones(1.0 eq.)andα-isocyano esters(1.2 eq.)in CH2Cl2 with Et3N(1.2 eq.)at room temperature for 24 h.The structures were confirmed by 1H NMR,13C NMR and MS(ESI).