摘要
N6-甲基腺苷(m6A)是目前最常见的真核mRNA甲基化修饰类型之一,在神经系统中广泛存在并参与控制基因表达重要调控机制。在相关甲基化修饰酶和蛋白的参与下,m6A通过影响mRNA“生命周期”进而在神经系统的生长发育、相关功能、疾病的发生发展等方面发挥着重要作用。文中将就mRNA m6A甲基化修饰对神经系统疾病以及神经系统生长发育的作用研究进展做简要综述。
N6-methyladenosine(m6A),one of the most common types of eukaryotic mRNA methylation modification,is widely distributed in the nervous system and participates in important regulatory mechanisms for controlling gene expression.With the participation of related methylation-modifying enzymes and proteins,m6A plays an important role in the growth and development of the nervous system,related functions,and the occurrence and development of diseases in the nervous system by affecting the"life cycle"of mRNA.This article briefly reviews the research progress on the role of mRNA m6A methylation modification in neurological diseases and nervous system growth and development.
作者
李冉
郝延磊
Li Ran;Hao Yanlei(Cheeloo College of Medicine,Shandong University,Jinan 250100,China;Department of Neurology,Affiliated Hospital of Jining Medical University,Jining,Shandong 272000,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2020年第10期819-823,共5页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目(81771360)。
