补体系统在动脉粥样硬化性心血管疾病中的研究与应用

Research and application of complement system in atherosclerotic cardiovascular disease

动脉粥样硬化性心血管疾病(ASCVD)仍是全球死亡的主要原因。补体系统是连接先天性和适应性免疫的桥梁,多种补体成分可通过影响炎症反应、血管重塑、血栓形成等过程,参与动脉粥样硬化的发生和发展。近年来,补体水平、补体激活产物及补体调节蛋白的临床检验价值日益凸显;补体相关生物标志物的应用也为ASCVD的诊断、预测、危险评估及预后判断提供了重要的参考依据。本文阐述补体系统参与ASCVD的病理生理学机制以及补体相关生物标志物在ASCVD风险方面的应用。

Atherosclerotic cardiovascular disease(ASCVD)remains the leading cause of death globally.The complement system is a bridge connecting innate and adaptive immunity.A variety of complement components may participate in the occurrence and development of atherosclerosis by affecting inflammatory responses,vascular remodeling and thrombosis.In recent years,the clinical values of complement levels,complement activation products and complement regulatory proteins have become increasingly prominent,and the application of complement-related biomarkers could provide an important reference for the diagnosis,prediction,risk assessment and prognosis evaluation of ASCVD.In this review,we focused on the pathophysiological mechanism of the complement system involved in ASCVD and the application of complement-related biomarkers associated with risk of ASCVD.