甲强龙鼓室给药联合不同疗程高压氧治疗突发性聋的疗效及影响因素分析

Analysis on the Curative Effect and Influencing Factors of Solumedrol Tympanum Administration Combined with Different Courses of Hyperbaric Oxygen in the Treatment of Sudden Deafness

目的探讨甲强龙鼓室给药联合不同疗程高压氧治疗突发性聋的疗效及影响因素。方法 162例(162耳)患者突聋随机分为A组和B组,每组各81例。两组在采用相同扩张血管、抗纤溶及营养神经治疗的基础上,A组接受甲强龙鼓室给药联合20次高压氧治疗,B组接受甲强龙鼓室给药联合10次高压氧治疗,比较两组疗效;依据临床疗效分为有效组(101例)与无效组(61例),分析影响疗效的相关因素。结果 A、B组治疗后平均纯音听阈(分别为48.9±7.7和48.0±8.5 dB HL)均较治疗前(分别为70.8±11.6和68.3±10.9 dB HL)明显改善(P<0.05),但两组间无统计学差异(P>0.05);A组、B组治疗总有效率分别为64.2%(52/81)、60.5%(49/81),差异无统计学意义(P>0.05)。有效组病程、伴眩晕、初诊听阈、全聋型、入院至开始高压氧治疗间隔天数与无效组相比,差异有统计学意义(P<0.05),多因素回归分析显示,病程、伴眩晕、全聋型、入院至开始高压氧治疗间隔天数对疗效有显著影响(P<0.05)。结论甲强龙鼓室给药联合10次或20次高压氧治疗突聋疗效无明显差异,病程、伴眩晕、全聋型、入院至开始高压氧治疗时间与疗效有关。

Objective To study the curative effect and influencing factors of solumedrol tympanum administration combined with different courses of hyperbaric oxygen in the treatment of sudden deafness(SD).Methods A total of 162 cases(162 ears)of SD patients were randomly divided into group A and group B,with 81 cases in each group.Group A received solumedrol tympanotympanum administration combined with 20 times of hyperbaric oxygen therapy,and group B received solumedrol tympanotympanum administration combined with 10 times of hyperbaric oxygen therapy.The difference of hearing improvement and clinical efficacy after treatment between the two groups was compared.According to the clinical efficacy,the two groups were divided into the effective group(n=101)and the ineffective group(n=61),and the relevant factors affecting the efficacy were analyzed.Results After treatment,the average pure tone hearing threshold in both groups was improved(P<0.05),but there was no statistical difference in the hearing improvement between the two groups(P<0.05).The total effective rates of group A and group B were 64.2%and 60.5%,respectively,with no statistically significant difference(P>0.05).Compared with the ineffective group,the effective group had a statistically significant difference in course of disease,vertigo,hearing threshold at initial diagnosis,total deafness,and days between admission and hyperbaric oxygen treatment(P<0.05).Multivariate regression analysis showed that course of disease,accompanied by vertigo,total deafness,and days between admission and hyperbaric oxygen treatment had significant effects on the efficacy(P<0.05).Conclusion There was no significant difference in the efficacy of tympantrum medronone combined with 10 or 20 times of hyperbaric oxygen in the treatment of SD.The course of disease,accompanied by vertigo,total deafness,and the length of time between admission and hyperbaric oxygen treatment were related to the efficacy.