内皮微颗粒与亚急性1,2-二氯乙烷中毒性脑病相关性

Correlation between endothelial microparticles and subacute 1,2-dichloroethane toxic encephalopathy

目的探讨内皮微颗粒(EMPs)与亚急性1,2二氯乙烷(1,2-DCE)中毒性脑病严重程度的关系。方法采用方便抽样方法,选择24例亚急性1,2-DCE中毒性脑病患者为病例组,以24名健康人群为对照组。采集2组人群空腹周围静脉血分离血浆,以流式细胞术检测血浆中EMPs水平。结果对照组人群血浆中EMPs水平为(692.0±174.4)×10^3个/L,病例组及其轻、中、重度亚组患者血浆中EMPs水平分别为(839.8±155.8)×10^3、(691.6±101.9)×10^3、(900.6±46.6)×10^3、(1026.8±69.8)×10^3个/L。病例组患者血浆中EMPs水平高于对照组(P<0.01);中、重度亚组患者EMPs水平分别高于对照组和轻度亚组(P<0.01)。结论亚急性1,2-DCE中毒性脑病患者存在内皮损伤,且内皮损伤与中毒严重程度具有一定关联。

Objective To explore the correlation between endothelial microparticles(EMPs)and subacute 1,2-dichloroethane(1,2-DCE)toxic encephalopathy.Methods A total of 24 patients with subacute 1,2-DCE toxic encephalopathy were selected as the case group,and 24 healthy individuals were selected as the control group using a convenient sampling method.Blood plasma was collected from the fasting venous blood of patients in these two groups,and the level of EMPs in the plasma was detected by flow cytometry.Results The levels of plasma EMPs of patients in the control group and the case group were(692.0±174.4)×10^3/L and(839.8±155.8)×10^3/L respectively.The levels of plasma EMPs in patients with mild,moderate and severe case subgroups were(691.6±101.9)×10^3/L,(900.6±46.6)×10^3/L and(1026.8±69.8)×10^3/L respectively.The EMPs level of patients in the case group was higher than that of the control group(P<0.01).The level of EMPs in the moderate and severe case subgroups was higher than that of the control group and mild case subgroup(P<0.01).Conclusion Endothelial injury was found in patients with subacute 1,2-DCE toxic encephalopathy and endothelial injury is related to the severity of poisoning.