丙硫氧嘧啶治疗妊娠合并甲状腺功能亢进对甲状腺激素水平和妊娠结局的影响

Effect of propylthiouracil on thyroid hormone level and pregnancy outcome in the treatment of pregnancy with hyperthyroidism

目的分析丙硫氧嘧啶治疗妊娠合并甲状腺功能亢进对甲状腺激素水平和妊娠结局的影响。方法选取本院2018年2月至2019年7月收治的46例妊娠合并甲状腺功能亢进患者,根据治疗方式的不同分为研究组和对照组,每组23例。对照组给予甲巯咪唑片治疗,研究组给予丙硫氧嘧啶治疗。观察两组患者治疗后的甲状腺激素水平[促甲状腺激素(TSH)、血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、血清总甲状腺素(TT4)]、不良反应妊娠结局发生情况。结果治疗后,研究组TSH水平高于对照组(P<0.05),FT3、FT4、TT4水平均低于对照组(P<0.05),且研究组剖宫产、早产、胎儿畸形、胎儿窘迫等不良妊娠结局的发生率低于对照组(P<0.05)。结论丙硫氧嘧啶可有效改善妊娠合并甲状腺功能亢进患者的甲状腺激素水平,疗效显著,且用药后不良反应发生率较低,安全性较高,值得推广。

Objective To analyze the effect of propylthiouracil on the level of thyroid hormone and the outcome of pregnancy.Methods 46 pregnant patients with hyperthyroidism admitted to our hospital from February 2018 to July 2019 were selected.According to different treatment methods,they were divided into study group and control group,with 23 cases in each group.The control group was treated with methimidazole tablets and the study group was treated with propyl thiouracil.The thyroid hormone levels(TSH),serum free triiodomethyl-adenoprogenine(FT3),serum free thyroxine(FT4),serum total thyroxine(TT4)and adverse reactions were observed between two groups after treatment.Results After treatment,TSH level in the study group was higher than that in the control group(P<0.05),FT3,FT4 and TT4 levels were lower than those in the control group(P<0.05),and the incidence of adverse pregnancy outcomes such as cesarean section,premature delivery,fetal malformation and fetal distress in the study group were lower than that in the control group(P<0.05).Conclusion Propylthiouracil can effectively improve the level of thyroid hormone in pregnant women with hyperthyroidism.The curative effect is remarkable.Moreover,the incidence of adverse reactions is low and the safety is high.