老年精神分裂症患者认知功能状况及影响因素分析

Analysis of the cognitive function and influencing factors in elderly patients with schizophrenia

目的分析老年精神分裂症患者的认知功能状况,探讨影响认知功能的相关因素。方法选取我院收治的112例老年精神分裂症患者作为观察组,采用重复性成套神经心理状态测验(RBANS)测定认知功能,阳性和阴性症状量表(PANSS)评估临床症状,简易智力状态检查量表(MMSE)分析智力水平。收集患者人口学资料、病程以及药物治疗方案等资料。同时选取50例健康老年人作为对照组,采用RBANS测定认知功能。采用单因素和多因素logistic回归分析方法分析相关影响因素。结果观察组RBANS评分总分及5项因子评分均低于对照组(P均<0.05或0.01)。高中以下学历、阴性症状≥22分和使用高含量抗胆碱能药物是影响认知功能的危险因素(P均<0.05)。结论老年精神分裂症患者认知功能下降。文化程度较低、阴性症状为主以及使用高含量抗胆碱能药物是影响认知功能的危险因素。

Objective To analyze the cognitive function of elderly patients with schizophrenia and explore the related factors.Methods A total of 112 elderly schizophrenia patients treated in our hospital were recruited as study subjects(the observation group).The repetitive neuropsychological state test(RBANS)was used to detect the cognitive function of the patients,the positive and negative symptoms scale(PANSS)was used to evaluate the clinical symptoms,and the MMSE was used to analyze the intelligence level.The date of demographic,course of disease and treatment were collected.A total of 50 healthy elderly people were selected as the control group.Single-factor and multi-factor Logistics regression analysis was used to analyze the relevant influencing factors.Results The total RBANS score and five factors scores in the observation group were lower than that in the control group(P<0.05).Education below high school level,negative symptoms≥22 points,and high content of anticholinergic drugs were risk factors affecting cognitive function(P<0.05).Conclusion The cognitive funcation of elderly patients with schizophrenia was declined,with less education,negative symptoms and high levels of anticholinergic drugs were risk factors for cognitive function.