NT-pro BNP在手足口病患儿中的表达及临床意义

Expression and significance of NT-pro BNP in children with hand-foot-mouth disease

目的探讨氨基末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-pro BNP)在手足口病(hand-footmouth disease,HFMD)患儿血清中的表达及其临床意义。方法收集2013年1月—2017年8月在鄂州市中心医院、鄂州市第二医院及广西中医药大学第一附属医院诊治的185例HFMD患儿的临床资料,185例中重症HFMD患儿110例,普通HFMD患儿75例;采用多因素Logistic回归分析重症HFMD患儿的相关危险因素及死亡危险因素。分析血清NT-pro BNP在重症HFMD患儿中的表达情况。采用Pearson相关分析分析血清NT-pro BNP与小儿危重病例评分的相关性。结果死亡重症HFMD患儿血清NT-pro BNP均值为(4846.50±314.61)ng/L,表达水平明显高于非死亡重症HFMD患儿的[(1468.07±454.58)ng/L];多因素Logistic回归分析结果表明NT-pro BNP是重症HFMD及死亡的危险因素(P均<0.05);Pearson相关分析结果显示血清NT-pro BNP表达水平与小儿危重病例评分呈负相关(r=-0.771,P=0.000)。结论血清NTpro BNP可以作为一个有效生物标志物,对评估重症HFMD患儿的预后具有良好的参考价值。

Objective To investigate the expression of N-terminal pro-brain natriuretic peptide(NT-pro BNP)in serum of children with hand-foot-mouth disease(HFMD)and its clinical significance.Methods From January 2013 to August 2017,clinical data of 185 children with HFMD who were treated in Ezhou Central Hospital,Ezhou Second Hospital and the First Affiliated Hospital of Guangxi University of Chinese Medicine were collected,including 110 children with moderate to severe HFMD and 75 children with common HFMD.Multivariate Logistic regression analysis was used to analyze the relevant risk factors and the death risk factors in children with severe HFMD.The expression of serum NT-pro BNP was analyzed in children with severe HFMD.The association of NT-pro BNP with pediatric critical illness scores was examined by pearson correlation analysis.Results The average serum NT-pro BNP level was(4846.50±314.61)ng/L in dead children with severe HFMD,and the expression level was significantly higher than that in non-dead children with severe HFMD,(1468.07±454.58)ng/L.Multivariate Logistic regression analysis showed that NT-pro BNP was a risk factor for severe HFMD and death(P<0.05);Pearson correlation analysis showed that serum NT-pro BNP expression level was negatively correlated with pediatric critical illness scores(r=-0.771,P=0.000).Conclusions Serum NT-pro BNP can be used as an effective biomarker,which has a good reference value for the prognosis of children with severe HFMD.