国医大师治疗失眠用药规律分析

An Analysis of Medication Rules of TCM Masters in Treating Insomnia

目的:基于数据挖掘技术,深层次挖掘国医大师治疗失眠的用药规律。方法:计算机检索中国知网、万方数据库、维普资讯等数据库,以"失眠"或"不寐"为关键词,逐一对90位国医大师治疗失眠的相关文献进行检索。通过中医传承辅助平台V2.5,对国医大师治疗失眠的用药规律进行分析。结果:最终纳入有效处方167首,共涉及208味药物。其中高频次药物为酸枣仁、茯苓、龙骨、牡蛎等,高频药物组合为"茯苓、酸枣仁""龙骨、牡蛎""龙骨、酸枣仁"等,核心组合包括"龙齿、石斛、天花粉""琥珀、石斛、北沙参""远志、茯苓、柏子仁"等,形成新处方"琥珀-石斛-北沙参-龙齿-天花粉""远志-茯苓-柏子仁-丹参-白术""大枣-生姜-桂枝-石菖蒲-红参"等。结论:国医大师治疗失眠以补益心脾、镇心安神为治疗原则,用药除重用安神类药物外,还喜用滋阴类、理气类、消食类等药物配伍,尤其是健脾消食类药物居多。

Objective:To deeply mine the medication rules of TCM masters in the treatment of insomnia based on data mining technology.Methods:By searching CNKI,Wanfang database,VIP information and other databases with the key words of"insomnia"or"Bu Mei",the relevant articles of 90 TCM masters on insomnia treatment were searched one by one.Through the TCM inheritance auxiliary platform V2.5,the medication rules of TCM masters in the treatment of insomnia were analyzed.Results:Finally,167 effective formulas were included,involving 208 kinds of medicinals.Among them,the high frequency medicinals included Suanzaoren(Semen Ziziphi Spinosae),Fuling(Poria),Longgu(Os Draconis),Muli(Concha Ostreae),etc.The high frequency medicinal combinations included"Fuling-Suanzaoren""Longgu-Muli""Longgu-Suanzaoren",etc.The core combinations included"Longchi(Dens Draconis)-Shihu(Caulis Dendrobii)-Tianhuafen(Radix Trichosanthis)""Hupo(Succinum)-Shihu(Caulis Dendrobii)-Beishashen(Radix Glehniae)""Yuanzhi(Radix Polygalae)-Fuling(Poria)-Baiziren(Semen Platycladi)",etc.The formed new formulas included"Hupo-Shihu-Beishashen-Longchi-Tianhuafen""Yuanzhi-Fuling-Baiziren-Danshen(Radix Salviae Miltiorrhizae)-Baizhu(Rhizoma Atractylodis Macrocephalae)""Dazao(Fructus Jujubae)-Shengjiang(Rhizoma Zingiberis Recens)-Guizhi(Ramulus Cinnamomi)-Shichangpu(Rhizoma Acori Tatarinowii)-Hongshen(Radix et Rhizoma Ginseng Rubra)"etc.Conclusion:In terms of insomnia,TCM masters regard nourishing heart and spleen,setting heart and calming mind as the treating principle.In terms of medicinals,besides a large amount of tranquilizing medicinals,medicinals for nourishing yin,or regulating qi,or promoting digestion,especially the ones for activating spleen and promoting digestion etc.are often used for compatibilities.