米索前列醇在足月胎膜早破孕妇中的应用

Application of Misoprostol in pregnant women with premature rupture of full-term membranes

目的探讨米索前列醇在足月胎膜早破中的应用效果。方法选取2018年6月~2019年9月本院收治的100例足月胎膜早破孕妇为研究对象,按照随机数字表法分为观察组和对照组,各50例。对照组使用缩宫素,观察组使用米索前列醇,比较两组产妇产程、产妇用药前后的激素水平、母婴结局以及用药不良反应等指标。结果观察组第一产程、第二产程、第三产程时间均短于对照组,差异有统计学意义(P<0.05)。两组孕妇用药6 h后的血清孕酮(P)低于治疗前,而血清前列腺素E(PGE)、血清雌激素(E2)水平高于治疗前,且观察组用药6 h后的血清P低于对照组,血清PGE、E2高于对照组,差异均有统计学意义(P<0.05)。观察组剖宫产率低于对照组,差异有统计学意义(P<0.05)。两组产后出血率、新生儿窒息、胎儿窘迫等比较,差异无统计学意义(P>0.05)。两组产妇用药期间不良反应比较,差异无统计学意义(P>0.05)。结论米索前列醇在足月胎膜早破引产中有重要的应用价值,能够快速帮助产妇改善激素水平,改善母婴结局,且具有较高的用药安全性。

Objective To investigate the application effect of Misoprostol in premature rupture of fetal membrane at term.Methods From June 2018 to September 2019,a total of 100 cases of premature rupture of membranes to full term pregnant women treated in our hospital were selected as the research objects.According to the random number table,they were divided into observation group and control group,each with 50 cases.The control group accetped Oxytocin,observation group accetped Misoprostol,maternal labor,hormone levels before and after medication,maternal and infant outcomes,adverse drug reactions and other indicators of the two groups were compared.Results The first,second and third stages of labor in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The serum progesterone(P)of the two groups of pregnant women 6 h after treatment was lower than that before treatment,while the serum prostaglandin E(PGE)and serum estrogen(E2)levels were higher than those before treatment,and the serum P of the observation group 6 h after treatment was lower than that of the control group,serum PGE,E2 were higher than those of the control group,the differences were statistically significant(P<0.05).The cesarean section rate in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences in the rate of postpartum hemorrhage,neonatal asphyxia,and fetal distress between the two groups(P>0.05).There were no statistically significant differences in the adverse reactions between the two groups of parturients during the medication period(P>0.05).Conclusion Misoprostol has important application value in the induction of labor with full-term premature rupture of membranes.It can quickly help mothers improve hormone levels,improve maternal and infant outcomes,and has high drug safety.