氧驱雾化吸入防治喉癌患者放射性口腔黏膜反应的效果

Effect of oxygen-driven atomization inhalation on the prevention and treatment of radioactive oral mucosal reaction in patients with laryngeal cancer

目的探讨氧驱雾化吸入防治喉癌患者放射性口腔黏膜反应的效果。方法选取2017年2月~2019年7月在江西省赣州市肿瘤医院行放射治疗的101例喉癌患者为研究对象,按照随机数字表法分为对照组(50例)与观察组(51例)。两组均行常规口腔护理,同时对照组行超声雾化吸入治疗,观察组行氧驱雾化吸入治疗。比较两组患者治疗前、放射治疗剂量33 Gy、结束放射治疗以及结束放射治疗1周时的唾液流量、口腔pH值以及放射治疗剂量33 Gy、结束放射治疗以及结束放射治疗1周时的放射性口腔黏膜反应发生情况。结果观察组放射治疗剂量33 Gy、结束放射治疗以及结束放射治疗1周时的口腔pH值均高于对照组,差异有统计学意义(P<0.05);观察组放射治疗剂量33 Gy、结束放射治疗以及结束放射治疗1周时的唾液流量均大于对照组,差异有统计学意义(P<0.05);观察组放射治疗剂量33 Gy、结束放射治疗以及结束放射治疗1周时的放射性口腔黏膜反应优于对照组,差异有统计学意义(P<0.05)。结论氧驱雾化吸入可有效防治喉癌患者放射性口腔黏膜反应。

Objective To explore the effect of oxygen-driven atomization inhalation on the prevention and treatment of radioactive oral mucosal reaction in patients with laryngeal cancer.Methods A total of 101 patients with laryngeal cancer who underwent radiotherapy in Ganzhou Tumor Hospital from February 2017 to July 2019 were selected.They were divided into the observation group(51 cases)and the control group(50 cases)according to the method of random digital table.Both groups were given routine oral nursing.Meanwhile,the control group received ultrasonic atomization inhalation therapy,and the observation group received oxygen-driven atomization inhalation therapy.The saliva flow,oral pH value at the time of before treatment,radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week and the occurrence of radioactive oral mucosal reaction at the time of radiotherapy dose 33Gy,the end of radiotherapy and the end of radiotherapy for 1 week were compared between the two groups.Results The oral pH value of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were higher than those of the control group,and the differences were statistically significant(P<0.05).The saliva flow of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were greater than those of the control group,and the differences were statistically significant(P<0.05).The radioactive oral mucosal reaction of the observation group at the time of radiotherapy dose 33 Gy,the end of radiotherapy and the end of radiotherapy for 1 week were better than those of the control group,the differences were statistically significant(P<0.05).Conclusion Oxygen-driven atomization inhalation can effectively prevent radioactive oral mucosal reaction in patients with laryngeal cancer.