阿替普酶溶栓与PCI治疗急性心肌梗死的效果比较

Effect comparison of ateplase thrombolysis and PCI in the treatment of acute myocardial infarction

目的比较分析阿替普酶溶栓以及经皮冠状动脉介入(PCI)对急性心肌梗死的疗效。方法选择100例急性心肌梗死患者病例,随机分为2组。对照组采用阿替普酶溶栓治疗,观察组采用PCI治疗。比较2组的预后、心血管不良事件发生情况和出血情况。结果观察组LVESD、CK-MB峰值明显低于对照组(P<0.05),再通率和LVEF明显高于对照组(P<0.05),2组LVEDD无明显差异(P>0.05);2组再梗死、心力衰竭、再发心绞痛和死亡的发生率无明显差异(P>0.05);2组鼻出血、牙龈出血、脑出血和消化道出血的发生率无明显差异(P>0.05)。结论与阿替普酶溶栓相比,对急性心肌梗死患者采取PCI治疗的效果更优,可以有效改善患者预后,提高动脉再通率。

Objective To compare the therapeutic effects of alteplase thrombolysis and percutaneous coronary intervention(PCI)on acute myocardial infarction.Methods One hundred patients with acute myocardial infarction were selected as subjects.All patients were divided into two groups randomly.The control group was treated with ateplase thrombolysis,while the observation group was treated with PCI.Prognosis,occurrence of cardiovascular adverse events and bleeding were compared between the two groups.Results The peak values of LVESD and CK-MB in the observation group were significantly lower than those in the control group(P<0.05),and the recanalization rate and LVEF were significantly higher than those in the control group(P<0.05).There was no significant difference in LVEDD between the two groups(P>0.05).There was no significant difference in the incidence of reinfarction,heart failure,recurrent angina pectoris and death between the two groups(P>0.05).There was no significant difference in the incidence of epistaxis,gingival bleeding,cerebral hemorrhage and gastrointestinal bleeding between the two groups(P>0.05).Conclusion Comparing with ateplase thrombolysis,PCI can effectively improve the prognosis of patients with acute myocardial infarction and improve the arterial recanalization rate.