眼部药物智能控释系统研究进展

Research progress on intelligent controlled drug release system for ophthalmic drug

药物智能控释系统又称刺激-响应型药物控释系统,是近年药物剂型研究的热点,通过外加磁场、超声波、光等刺激,以及温度、酸碱度等控制,结合相应的高分子材料,达到药物的靶向、实时可控、定量定向给药。眼部的药物智能控释系统研究起步较晚,目前主要仍为基于原位凝胶给药体系的控释系统,其他如磁场、超声、光等外加刺激控释系统仍在起步阶段。精准的靶向治疗是医学发展的必然要求,因此药物精准控释也是未来较为理想的给药方式。本文综述眼部的药物智能控释研究,为眼部给药研究提供参考。

The intelligent controlled drug release system,also known as the stimulus-responsive drug release system,has become a hotspot in the research of pharmaceutical dosage form in recent years.Through combining external magnetic field,ultrasound,light and other stimulants,as well as temperature and pH with corresponding polymer materials,targeted,real-time,quantitative and controlled drug release can be achieved.The research on the intelligent drug release system for ocular drugs has been conducted for a short period of time.The controlled release system based on the in-situ gel drug delivery system remains the major system.Other externally stimulated controlled release systems,such as magnetic field,ultrasound,and light,are still in their infancy.Precise targeted therapy is an inevitable requirement for medical development.Consequently,precise controlled release of drugs will become an ideal way of drug administration in the future.In this article,research progress on the intelligent controlled release for ophthalmic drugs was reviewed,aiming to provide reference for the research of ocular drug delivery.