血压变异性与肾脏血管内皮功能障碍的研究进展

Research progress on blood pressure variability and renal vascular endothelial dysfunction

血压变异性与血管内皮功能障碍及血管重构密切相关,是高血压引起靶器官损害的主要因素,是独立于血压平均值之外的对心脑血管等并发症发生风险的强预测因子。血管内皮细胞是高血压作用的靶器官之一,血管内皮功能障碍是高血压和血管老化的基础,其主要影响肾脏,导致肾血流动力学紊乱、血管内凝血激活和肾纤维化。该文将国内外血压变异性与肾脏血管内皮功能障碍的相关研究进行综述。

Blood pressure variability is intimately associated with vascular endothelial dysfunction and vascular remodeling,which is a strong predictor of the risk of cardiovascular and cerebrovascular complications independent of the mean blood pressure.Vascular endothelial cell is one of the target organs of hypertension and vascular endothelial dysfunction is the basis of hypertension and vascular aging,which mainly affects the kidney and leads to renal hemodynamic disorders,intravascular coagulation activation and renal fibrosis.In this article,the correlation between blood pressure variability and renal vascular endothelial dysfunction was reviewed.