痰湿型哮喘患者炎症因子IL-4、IL-5、IFN-γ表达特点及临床意义

Expression and clinical significance of inflammatory factors IL-4,IL-5 and IFN-γin patients with asthma of phlegm-dampness type

目的探讨痰湿型哮喘患者炎症因子白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、干扰素-γ(IFN-γ)表达水平及临床意义。方法选取2017年5月—2019年5月新疆医科大学第一附属医院诊治的痰湿型哮喘患者40例作为痰湿型哮喘组、非痰湿型哮喘患者37例作为非痰湿哮喘组,另选取同期体检健康者38例作为正常组。通过酶联免疫吸附试验检测3组受试者血清IL-4、IL-5、IFN-γ水平,并比较哮喘不同病情分级患者血清IL-4、IL-5、IFN-γ水平的差异。结果痰湿型哮喘组和非痰湿型哮喘组血清IL-4、IL-5水平均明显高于正常组(P均<0.05),IFN-γ水平均明显低于正常组(P均<0.05);痰湿型哮喘组血清IL-4、IFN-γ水平均明显低于非痰湿型哮喘组(P均<0.05),IL-5水平明显高于非痰湿型哮喘组(P<0.05)。痰湿型、非痰湿型哮喘不同分级患者血清IL-4、IL-5、IFN-γ水平比较差异均无统计学意义(P均>0.05)。结论哮喘患者痰湿体质与炎症因子IL-4、IL-5、IFN-γ水平关系密切,加强炎症状态监测及干预,对临床防治痰湿型哮喘具有重要意义。

Objective It is to investigate the expression levels and clinical significance of inflammatory factors interleukin-4(IL-4),interleukin-5(IL-5)and interferon-γ(IFN-γ)in patients with asthma of phlegm-dampness type.Methods 40 patients with phlegm-damp asthma diagnosed and treated in the First Affiliated Hospital of Xinjiang Medical University from May 2017 to May 2019 were selected as the phlegm-damp asthma group,and 37 patients with non-phlegm-dampness asthma as non-phlegm-dampness asthma group,38 healthy people were selected as normal group.The levels of serum IL-4,IL-5 and IFN-γin the three groups were detected by enzyme-linked immunosorbent assay(ELISA),and the differences in the levels of serum IL-4,IL-5 and IFN-γin patients with different grades of asthma were compared.Results The levels of serum IL-4 and IL-5 in the phlegm-dampness asthma group and non-phlegm-dampness asthma group were significantly higher and the levels of IFN-γwere significantly lower than those in the normal group(all P<0.05);the levels of serum IL-4 and IFN-γin the phlegm-dampness asthma group were significantly lower than those in the non-phlegm-dampness asthma group(all P<0.05),and the level of IL-5 was significantly higher than that in the non-phlegm-dampness asthma group(P<0.05).There was no significant difference in serum IL-4,IL-5 and IFN-γlevels between patients with asthma of phlegm-dampness type and non-phlegm-dampness type in different grades(all P>0.05).Conclusion Phlegm-damp constitution of asthma patients is closely related to the levels of inflammatory factors IL-4,IL-5,and IFN-γ.Strengthening the monitoring and intervention of inflammation status is of great significance for the clinical prevention and treatment of phlegm-dampness asthma.