二甲双胍缓释片治疗2型糖尿病患者对血糖的影响研究

Effect of Metformin Sustained-release Tablets on Blood Glucose in Type 2 Diabetes

目的探讨2型糖尿病以二甲双胍缓释片治疗的临床效果及对其血糖水平的影响。方法选取该院2015年2月—2019年8月期间收治的45例2型糖尿病病例,以治疗药物的不同将其分为治疗组(n=23)与对照组(n=22),对照组采取格列吡嗪缓释片进行治疗,治疗组采取二甲双胍缓释片进行治疗,对两组治疗效果,血糖控制水平等进行对比分析。结果治疗组显效11例、有效10例、无效2例,其总有效率91.30%(21/23)显著高于对照组,比较差异有统计学意义(χ2=3.981,P<0.05);治疗前,两组血糖控制水平及糖化血红蛋白水平差异无统计学意义(P>0.05);治疗后均得到改善,治疗组治疗后空腹血糖水平(6.61±1.67)mmol/L,餐后2 h血糖水平(8.64±1.98)mmol/L,糖化血红蛋白水平(6.98±1.06)%更加优于对照组,差异有统计学意义(t=11.552、14.772、13.975,P<0.05)。结论2型糖尿病患者以二甲双胍缓释片治疗的临床效果优于格列吡嗪缓释片治疗效果,且可以更好地控制患者血糖水平,糖化血红蛋白水平,安全性好。

Objective To investigate the clinical effect of metformin sustained-release tablets in patients with type 2 diabetes and the influence on blood glucose levels.Methods A total of 45 cases of type 2 diabetes who were admitted to the hospital from February 2015 to August 2019 were selected and divided into treatment group(n=23)and control group(n=22)according to different treatment drugs.Control group adopted glipizide sustained-release tablets for treatment,and the treatment group adopted metformin sustained-release tablets for treatment.The therapeutic effects and blood glucose control levels of the two groups were compared and analyzed.Results In the treatment group,11 cases were markedly effective,10 cases were effective,and 2 cases were ineffective.The total effective rate 91.30%(21/23)was significantly higher than that of the control group.The difference was statistically significant(χ2=3.981,P<0.05);There was no statistically significant difference in blood glucose control level and glycosylated hemoglobin level in the group(P>0.05);both were improved after treatment.The fasting blood glucose level after treatment in the treatment group was(6.61±1.67)mmol/L,and the blood glucose level after meal 2 h(8.64±1.98)mmol/L,the level of glycosylated hemoglobin(6.98±1.06)%was better than that of the control group,and the difference was statistically significant(t=11.552,14.772,13.975,P<0.05).Conclusion The clinical effect of metformin sustained-release tablets in type 2 diabetes patients is better than that of glipizide sustained-release tablets,and it can better control the patient's blood glucose level,glycosylated hemoglobin level,and good safety.