甲钴胺联合前列地尔治疗糖尿病周围神经病变的治疗价值研究

Study on the Therapeutic Value of Mecobalamin Combined with Alprostadil in the Treatment of Diabetic Peripheral Neuropathy

目的分析甲钴胺联合前列地尔治疗糖尿病周围神经病变的治疗价值。方法将于2019年1—11月该院收治的102例糖尿病周围神经病变患者作为观察对象,随机分为观察组患者51例,对照组患者51例,对观察组给予甲钴胺联合前列地尔治疗,对照组患者实施前列地尔治疗,对比观察两组患者治疗前后振动感觉阈值、治疗效果、不良反应(面色潮红、食欲不振、腹胀)及患者病变(肢体麻木、灼烧刺痛感、四肢无力)发病次数。结果治疗前两组患者振动感觉阈值差异无统计学意义(P>0.05),治疗后观察组振动感觉阈值相比于对照组,分数较低且差异有统计学意义(P<0.05),观察组患者治疗有效率与对照组差异有统计学意义(P<0.05),观察组患者不良反应发生率与对照组比较,观察组不良反应发生率更低(P<0.05),观察组肢体麻木、灼烧刺痛感、四肢无力发病次数相比于对照组,差异有统计学意义(P<0.05),观察组治疗后空腹血糖与餐后2 h血糖相比于对照组更低,差异有统计学意义(P<0.05)。结论应用甲钴胺联合前列地尔治疗糖尿病周围神经病变,能够降低患者的肢体麻木感,提升活动能力,治疗效果显著,值得在治疗糖尿病周围神经病变中应用。

Objective To analyze the therapeutic value of mecobalamin combined with alprostadil in the treatment of diabetic peripheral neuropathy.Methods The patients with diabetic peripheral neuropathy 102 cases admitted to the hospital from January to November 2019 will be randomly divided into observation group of 51 patients,control group of 51 patients,and the observation group will be given mecobalamin combined with alprostadil treatment,the control group of patients received alprostadil treatment,the two groups were compared and observed before and after treatment,the vibration sensory threshold,the treatment effect,adverse reactions(flushing,loss of appetite,abdominal distension)and patient lesions(numbness,burning of the limbs,weakness of limbs).Results Before treatment,there was no statistically significant difference in vibration perception threshold between the two groups of patients(P>0.05).After treatment,the vibration perception threshold of the observation group was lower than that of the control group and the difference was statistically significant(P<0.05).The treatment efficiency of the observation group was compared with the control group,the effective rate was higher(P<0.05),the incidence of adverse reactions in the observation group was compared with the control group,the incidence of adverse reactions in the observation group was lower(P<0.05),the observation group had numbness,burning and tingling,and limbs compared with the control group,the number of times of weakness was less and the difference was statistically significant(P<0.05).The fasting blood glucose after treatment and the 2 h postprandial blood glucose in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion The application of mecobalamin combined with alprostadil in the treatment of diabetic peripheral neuropathy can reduce the numbness of the patient's limbs,improve mobility,and have a significant therapeutic effect.It is worthy of application in the treatment of diabetic peripheral neuropathy.