急诊科治疗急性酒精中毒的临床研究

Clinical Study on the Treatment of Acute Alcoholism in Emergency Department

目的探究急诊科急性酒精中毒患者采用醒脑静联合纳洛酮的治疗效果与安全性。方法于2018年10月—2019年10月,随机选取该院急诊科收治的68例急性酒精中毒患者,按照双盲法分为两组,对比组采用纳洛酮治疗,实验组患者采用纳洛酮联合醒脑静治疗,并对两组患的治疗总有效率、意识恢复、药物起效、症状改善、症状消失的时间、血清β-内啡肽、丙二醛水平以及不良反应发生率进行比较。结果实验组总有效率94.12%,与对比组的73.53%相对比较高(χ^2=5.314,P=0.021);实验组患者的意识恢复、药物起效、症状改善以及症状消失的时间均比对比组患者少(t=9.305、9.343、7.186、6.834,P<0.05);两组患者治疗前血清β-内啡肽与丙二醛水平的差异无统计学意义(P>0.05);对比组与实验组患者治疗后血清β-内啡肽与丙二醛水平均比治疗前的有所降低(P<0.05),并且实验组患者治疗后血清β-内啡肽与丙二醛水平的降低幅度比对比组大(t=10.032、7.848,P<0.05);实验组不良反应发生率5.88%,低于对比组患者的29.41%(χ^2=6.476,P=0.011)。结论急诊科急性酒精中毒患者采用醒脑静联合纳洛酮治疗的效果显著,不良反应较少。

Objective To explore the therapeutic effect and safety of Xingnaojing combined with naloxone in patients with acute alcoholism in the emergency department.Methods From October 2018 to October 2019,68 patients with acute alcoholism admitted to the emergency department of the hospital were randomly selected and divided into two groups according to the double-blind method.The control group was treated with naloxone,and the experimental group was treated with naloxone combined with Xingnaojing was used for treatment,and the total effective rate of treatment,recovery of consciousness,drug onset,improvement of symptoms,time to disappearance of symptoms,serumβ-endorphin,malondialdehyde levels,and adverse reactions to the two groups of patients were compared.Results The total effective rate of the experimental group was 94.12%,which was relatively higher than 73.53%of the control group(χ^2=5.314,P=0.021);the patients in the experimental group had recovery of consciousness,drug onset,improvement of symptoms and disappearance of symptoms compared with the control group(t=9.305,9.343,7.186,6.834,P<0.05;the two groups of patients before treatment of serumβ-endorphin and malondione in aldehyde levels was not statistically significant(P>0.05);the levels of serumβ-endorphin and malondialdehyde after treatment in the control group and the experimental group were higher than those before treatment(P<0.05),and the serumβ-endorphin and malondione of the experimental group after treatment of the reduction of aldehyde level was greater than that of the control group(t=10.032,7.848,P<0.05);the adverse reaction rate of the experimental group was 5.88%,which was lower than 29.41%of the control group(χ^2=6.476,P=0.011).Conclusion The effect of Xingnaojing combined with naloxone on patients with acute alcoholism in the emergency department is significant,with fewer adverse reactions.