甘精胰岛素联合阿卡波糖治疗2型糖尿病的疗效

Efficacy of Insulin Glargine Combined with Acarbose in the Treatment of Type 2 Diabetes

目的分析甘精胰岛素联合阿卡波糖在治疗2型糖尿病患者当中的临床效果。方法研究对象选择该院2018年12月—2019年12月期间接受治疗的120例2型糖尿病的患者。将所有患者按照数字随机表法划分为观察组和对照组,每组60例。对照组选择接受预混胰岛素治疗,观察组接受甘精胰岛素联合阿卡波糖治疗。在治疗结束后比较两组患者的糖化血红蛋白、空腹血糖、餐后2 h血糖指标,分析两组患者的动态血糖指标,总结治疗效果。结果观察组糖化血红蛋白范围(6.0±1.1)%、空腹血糖值(6.4±0.8)mmol/L、餐后2 h血糖值(8.9±0.6)mmol/L优于对照组(7.1±0.8)%、(7.6±1.0)mmol/L、(10.6±0.7)mmol/L,数据结果差异有统计学意义(t=3.389、3.692、3.811,P<0.05);观察组患者0 h(6.9±0.4)mmol/L、6 h(7.3±0.6)mmol/L、12 h(7.7±1.1)mmol/L、18 h(7.4±0.8)mmol/L、24 h(7.1±0.3)mmol/L不同时间点的血糖值均低于对照组血糖值(7.6±0.4)mmol/L、(8.0±0.3)mmol/L、(11.3±0.8)mmol/L、(9.2±0.4)mmol/L、(8.3±0.4)mmol/L,差异有统计学意义(t=3.614、3.603、3.904、3.776、3.703,P<0.05)。结论甘精胰岛素联合阿卡波糖在治疗2型糖尿病患者的过程中可以发挥显著的作用,一方面帮助患者维持较稳定的血糖水平,避免低血糖或治疗效果不佳;另一方面阿卡波糖可以直接随饭服用,无需额外进行用药。

Objective To analyze the clinical effect of insulin glargine combined with acarbose in the treatment of type 2 diabetes patients.Methods The study subjects selected 120 patients with type 2 diabetes who were treated in the hospital from December 2018 to December 2019.All patients were divided into observation group and control group according to the number random table method,with 60 cases in each group.The control group received premixed insulin therapy,and the observation group received insulin glargine combined with acarbose therapy.After the treatment,the glycosylated hemoglobin,fasting blood glucose,and 2h postprandial blood glucose indexes of the two groups were compared,and the dynamic blood glucose indexes of the two groups were analyzed to summarize the treatment effect.Results The glycated hemoglobin range of the observation group was(6.0±1.1)%,the fasting blood glucose value was(6.4±0.8)mmol/L,and the postprandial blood glucose value of(8.9±0.6)mmol/L was better than the control group by(7.1±0.8)%,(7.6±1.0)mmol/L,(10.6±0.7)mmol/L,the data results was statistical significance difference(t=3.389,3.692,3.811,P<0.05);observation group patients 0 h(6.9±0.4)mmol/L;the blood glucose values of 6 h(7.3±0.6)mmol/L,12 h(7.7±1.1)mmol/L,18 h(7.4±0.8)mmol/L,24 h(7.1±0.3)mmol/L at different time points are all lower than the blood glucose levels of the control group were(7.6±0.4)mmol/L,(8.0±0.3)mmol/L,(11.3±0.8)mmol/L,(9.2±0.4)mmol/L,(8.3±0.4)mmol/L,the difference was statistically significant(t=3.614,3.603,3.904,3.776,3.703,P<0.05).Conclusion Insulin glargine combined with acarbose can play a significant role in the treatment of patients with type 2 diabetes.On the one hand,it helps patients maintain a relatively stable blood sugar level and avoid hypoglycemia or poor treatment effects;on the other hand, acarbose glucose can be taken directly with meals without additional medication.